N
Nicole Hannesschläger
Researcher at Technische Universität München
Publications - 7
Citations - 2423
Nicole Hannesschläger is an academic researcher from Technische Universität München. The author has contributed to research in topics: Inflammasome & Innate immune system. The author has an hindex of 6, co-authored 7 publications receiving 2195 citations.
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Journal ArticleDOI
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.
Olaf Gross,Olaf Gross,Hendrik Poeck,Michael Bscheider,Catherine Dostert,Nicole Hannesschläger,Stefan Endres,Gunther Hartmann,Aubry Tardivel,Edina Schweighoffer,Victor L. J. Tybulewicz,Attila Mócsai,Jürg Tschopp,Jürgen Ruland +13 more
TL;DR: The results demonstrate the molecular basis for IL-1β production after fungal infection and identify a crucial function for the Nlrp3 inflammasome in mammalian host defence in vivo.
Journal ArticleDOI
A Homozygous CARD9 Mutation in a Family with Susceptibility to Fungal Infections
Erik-Oliver Glocker,André Hennigs,Mohammad Nabavi,Alejandro A. Schäffer,Cristina Woellner,Ulrich Salzer,Dietmar Pfeifer,Hendrik Veelken,Klaus Warnatz,F Tahami,Sarah Jamal,Annabelle Manguiat,Nima Rezaei,Ali Akbar Amirzargar,Alessandro Plebani,Nicole Hannesschläger,Olaf Gross,Jürgen Ruland,Bodo Grimbacher +18 more
TL;DR: Functional studies based on genetic reconstitution of myeloid cells from Card9(-/-) mice showed that the Q295X mutation impairs innate signaling from the antifungal pattern-recognition receptor dectin-1.
Journal ArticleDOI
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1|[beta]| production
Hendrik Poeck,Michael Bscheider,Olaf Gross,Olaf Gross,Katrin Finger,Susanne Roth,Manuele Rebsamen,Nicole Hannesschläger,Martin Schlee,Simon Rothenfusser,Winfried Barchet,Hiroki Kato,Shizuo Akira,Satoshi Inoue,Satoshi Inoue,Stefan Endres,Christian Peschel,Gunther Hartmann,Veit Hornung,Jürgen Ruland +19 more
TL;DR: The results identify the CARD9–Bcl-10 module as an essential component of the RIG-I-dependent proinflammatory response and establish Rig-I as a sensor able to activate the inflammasome in response to certain RNA viruses.
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production (vol 11, pg 63, 2010)
Hendrik Poeck,Michael Bscheider,O Gross,K Finger,S Roth,M Rebsamen,Nicole Hannesschläger,Martin Schlee,S Rothenfusser,W Barchet,Hiroki Kato,Shizuo Akira,S Inoue,S Endres,C Peschel,G Hartmann,Hornung,J Ruland +17 more
Journal ArticleDOI
Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.
Konstantin Neumann,Mercedes Castineiras-Vilarino,Ulrike Höckendorf,Nicole Hannesschläger,Simone Lemeer,Danny Kupka,Svenia Meyermann,Maciej Lech,Hans-Joachim Anders,Bernhard Kuster,Dirk H. Busch,Andreas Gewies,Ronald Naumann,Olaf Groß,Jürgen Ruland +14 more
TL;DR: A negative regulatory MSU receptor that controls noninfectious inflammation in response to cell death that has implications for autoimmunity and inflammatory disease is identified.