S
Simona Cavalieri
Researcher at University of Turin
Publications - 35
Citations - 1154
Simona Cavalieri is an academic researcher from University of Turin. The author has contributed to research in topics: Ataxia & Ataxia-telangiectasia. The author has an hindex of 18, co-authored 35 publications receiving 1047 citations.
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Journal ArticleDOI
Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence.
Simona Cavalieri,Sabrina Cazzaniga,Massimo Geuna,Zulma Magnani,Claudio Bordignon,Luigi Naldini,Chiara Bonini +6 more
TL;DR: In this paper, the authors tested lentiviral vectors (LVs) and stimulation with cytokines involved in antigen-independent T-cell homeostasis, such as interleukin 7 (IL-7), IL-2, and IL-15.
Journal ArticleDOI
Robust and Efficient Regulation of Transgene Expression in Vivo by Improved Tetracycline-Dependent Lentiviral Vectors
Elisa Vigna,Simona Cavalieri,Laurie Ailles,Massimo Geuna,Rainer Loew,Hermann Bujard,Luigi Naldini +6 more
TL;DR: A panel of lentiviral vectors displayed tetracycline-regulated transgene expression over two orders of magnitude in bulk, non-selected populations of transduced cells in vitro and in vivo, demonstrating integration of the regulated expression system into long-term repopulating cells.
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Molecular Evidence of Lentiviral Vector-Mediated Gene Transfer into Human Self-Renewing, Multi-potent, Long-Term NOD/SCID Repopulating Hematopoietic Cells
Laurie Ailles,Manfred Schmidt,Francesca R. Santoni de Sio,Hanno Glimm,Simona Cavalieri,Stefania Bruno,Wanda Piacibello,Christof von Kalle,Luigi Naldini +8 more
TL;DR: Although SRC transduction was efficient without stimulation, the presence of cytokines significantly improved it, and the first formal demonstration that primitive human HSC with self-renewal and multi-lineage repopulation capacities were transduced by lentiviral vectors is provided.
Journal ArticleDOI
A rapid flow cytometry test based on histone H2AX phosphorylation for the sensitive and specific diagnosis of ataxia telangiectasia
Paola Porcedda,Valentina Turinetto,Alfredo Brusco,Simona Cavalieri,Erica Lantelme,Luca Orlando,Umberto Ricardi,Antonio Amoroso,Dario Gregori,Claudia Giachino +9 more
TL;DR: A new flow cytometry method based on the measurement of histone H2AX phosphorylation that may be proposed for the early differential diagnosis of A‐T as an alternative to methods requiring the production of LCLs.