M
Manfred Schmidt
Researcher at University of Mainz
Publications - 244
Citations - 15836
Manfred Schmidt is an academic researcher from University of Mainz. The author has contributed to research in topics: Polymer & Copolymer. The author has an hindex of 63, co-authored 244 publications receiving 15131 citations. Previous affiliations of Manfred Schmidt include University of Bayreuth & École Polytechnique Fédérale de Lausanne.
Papers
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Journal ArticleDOI
A Serious Adverse Event after Successful Gene Therapy for X-Linked Severe Combined Immunodeficiency
Salima Hacein-Bey-Abina,Christof von Kalle,Manfred Schmidt,Françoise Le Deist,NM Wulffraat,Elisabeth McIntyre,Isabelle Radford,Jean-Luc Villeval,Christopher Fraser,Marina Cavazzana-Calvo,Alain Fischer +10 more
TL;DR: The sustained correction of X-linked severe combined immunodeficiency disease by ex vivo, retrovirally mediated transfer of the γc gene into CD34+ cells in four of five patients with the disease has been reported.
Journal ArticleDOI
Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector
H. Bobby Gaspar,Kathryn L. Parsley,Steven J. Howe,Doug King,Kimberly Gilmour,Kimberly Gilmour,Joanna Sinclair,Gaby Brouns,Manfred Schmidt,Christof von Kalle,Torben Barington,Marianne Antonius Jakobsen,Hans Ole Christensen,Abdulaziz Al Ghonaium,Harry N White,John L. Smith,Roland J. Levinsky,Robin R. Ali,Christine Kinnon,Adrian J. Thrasher,Adrian J. Thrasher +20 more
TL;DR: Gene therapy for SCID-X1 is a highly effective strategy for restoration of functional cellular and humoral immunity in patients with X-linked severe combined immunodeficiency.
Journal ArticleDOI
Effective gene therapy with nonintegrating lentiviral vectors
Rafael J. Yáñez-Muñoz,Rafael J. Yáñez-Muñoz,Rafael J. Yáñez-Muñoz,Kamaljit S. Balaggan,A MacNeil,Steven J. Howe,Manfred Schmidt,Manfred Schmidt,Alexander J. Smith,Prateek K. Buch,Robert E MacLaren,Patrick N. Anderson,S. E. Barker,Yanai Duran,CC Bartholomae,CC Bartholomae,Christof von Kalle,John R. Heckenlively,Christine Kinnon,Robin R. Ali,Adrian J. Thrasher +20 more
TL;DR: The high efficiency of gene transfer and expression mediated by lentiviruses can be harnessed in vivo without a requirement for vector integration and substantially reduces the risk of insertional mutagenesis.
Book ChapterDOI
Polyelectrolytes in solution
Stephan Förster,Manfred Schmidt +1 more
TL;DR: A review of polyelectrolyte solutions in polymer science can be found in this paper, where the authors demonstrate that the increasing effort in analytical theory, simulations and experiments is about to result in a deeper, fundamental understanding of the interacting macroions and of the conformational properties of flexible polyions.
Journal ArticleDOI
Temperature triggered self-assembly of polypeptides into multivalent spherical micelles.
Matthew R. Dreher,Andrew J. Simnick,Karl Fischer,Richard J.H. Smith,Anand G. Patel,Manfred Schmidt,Ashutosh Chilkoti +6 more
TL;DR: These studies have identified a subset of ELP(BC)'s bearing terminal peptide ligands that are capable of forming multivalent spherical micelles that present multiple copies of the ligand on their corona in the clinically relevant temperature range 37-42 degrees C and target cancer cells.