Simona Smiroldo

TL;DR: It is demonstrated that a short treatment with immunosuppressive agents, such as 1α,25-dihydroxyvitamin D3/mycophenolate mofetil, induces tolerance to islet allografts associated with an increased frequency of CD4+CD25+ regulatory cells that can adoptively transfer transplantation tolerance.

TL;DR: A short treatment of adult NOD mice with an analog of 1,25-dihydroxyvitamin D3 inhibits IL-12 production, blocks pancreatic infiltration of Th1 cells, enhances CD4CD25 regulatory cells, and arrests the progression of type 1 diabetes, suggesting its possible application in the treatment of human autoimmune diabetes.

TL;DR: Resuls indicate that inhibition of IL‐12‐dependent Th1 cell development is associated with effective treatment of CR‐EAE and suggest the feasibility of an approach based on low molecular weight inhibitors of IL-12 production in the treatment of multiple sclerosis.

TL;DR: The pathogenesis of autoimmune diabetes in NOD mice is correlated with both an enhanced pathogenicity ofCD4+CD25− T cells and a decreased suppressive activity of CD4-CD25+ T cells, consistent with the role of CD54 in diabetes development.

TL;DR: Results indicate that caspase-1 plays an important role in the early stage of the immune-mediated inflammatory process leading to EAE, thus representing a possible therapeutic target in the acute phase of relapsing remitting MS.