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TL;DR: A deeper involvement of phytocannabinoids (the key compounds in C. sativa) in several others central and peripheral pathophysiological mechanisms such as food intake, inflammation, pain, colitis, sleep disorders, neurological and psychiatric illness is suggested.

TL;DR: The results indicated that NESS 0327 is a novel cannabinoid antagonist with high selectivity for the cannabinoid CB1 receptor.

TL;DR: This review aims to clarify the pharmacological activity of CBD and its multiple therapeutic applications and critical and conflicting results of the research are discussed with a focus on promising future prospects.

TL;DR: The present article reviews the currently available knowledge on the herbal, synthetic and endogenous cannabinoids with respect to the modulation of anxiety responses, and highlights the challenges that should be overcome to harness the therapeutic potential of some of these compounds, all the while limiting the side effects associated with cannabis consumption.

TL;DR: It is shown that Bri2 BRICHOS monomers potently prevent neuronal network toxicity of Aβ, while dimers strongly suppress Aβ fibril formation, suggesting a means to generate molecular chaperone diversity.