S
Sinisa Dovat
Researcher at Pennsylvania State University
Publications - 125
Citations - 2426
Sinisa Dovat is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Leukemia & Ikaros Transcription Factor. The author has an hindex of 27, co-authored 100 publications receiving 1981 citations. Previous affiliations of Sinisa Dovat include Penn State Milton S. Hershey Medical Center & Children's Hospital Los Angeles.
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Journal ArticleDOI
A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains
TL;DR: It is demonstrated that all three linkers in the DNA-binding domain of Ikaros are phosphorylated during mitosis, suggesting that linker phosphorylation provides a global mechanism for inactivation of the C2H2 family.
Journal ArticleDOI
IL-7 Dependence in Human B Lymphopoiesis Increases during Progression of Ontogeny from Cord Blood to Bone Marrow
Yasmin Khan Parrish,Ineavely Baez,Terry Ann M. Milford,Abigail Benitez,Nicholas R. Galloway,Jaqueline W. Rogerio,Eva Sahakian,Mercy Kagoda,Grace Huang,Qian Lin Hao,Yazmar Sevilla,Lora Barsky,Ewa Zielinska,Mary A. Price,Nathan R. Wall,Sinisa Dovat,Kimberly J. Payne,Kimberly J. Payne +17 more
TL;DR: Examination of a novel, human-only model based on coculturing human HSCs on primary human BM stroma provides evidence that IL-7 is essential for human B cell production from adult BM and thatIL-7-induced expansion of the pro-B compartment is increasingly critical for humanB cell production during the progression of ontogeny.
Journal ArticleDOI
Ikaros Stability and Pericentromeric Localization Are Regulated by Protein Phosphatase 1
Marcela Popescu,Zafer Gurel,Tapani Ronni,Chunhua Song,Ka Ying Hung,Kimberly J. Payne,Sinisa Dovat +6 more
TL;DR: A model whereby the function of Ikaros is controlled by the CK2 and PP1 pathways and that a balance between these two signal transduction pathways is essential for normal cellular function and for the prevention of malignant transformation is proposed.
Journal ArticleDOI
RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1.
Irina Elcheva,Tyler Wood,Kathryn Chiarolanzio,Bryan Chim,Madeline Wong,Vikash Singh,Chethana P. Gowda,Qingli Lu,Markus Hafner,Sinisa Dovat,Zhenqiu Liu,Zhenqiu Liu,Stefan A. Muljo,Vladimir S. Spiegelman +13 more
TL;DR: It is reported that genetic or chemical inhibition of IGF2BP1 decreases leukemia cells’ tumorigenicity, promotes myeloid differentiation, increases leukemia cell death, and sensitizes leukemia cells to chemotherapeutic drugs.
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Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia
Chunhua Song,Chandrika Gowda,Xiaokang Pan,Yali Ding,Yongqing Tong,Bi-Hua Tan,Haijun Wang,Sunil Muthusami,Zheng Ge,Zheng Ge,Mansi Sachdev,Shantu Amin,Dhimant Desai,Krishne Gowda,Raghavendra Gowda,Gavin P. Robertson,Hilde Schjerven,Markus Müschen,Kimberly J. Payne,Sinisa Dovat +19 more
TL;DR: It is demonstrated that Ikaros controls cellular proliferation by repressing expression of genes that promote cell cycle progression and the phosphatidylinositol-3 kinase (PI3K) pathway and that CK2 is overexpressed in leukemia.