S
Sisi Liu
Researcher at Guangzhou Medical University
Publications - 3
Citations - 52
Sisi Liu is an academic researcher from Guangzhou Medical University. The author has contributed to research in topics: Kinase & HDAC4. The author has an hindex of 3, co-authored 3 publications receiving 22 citations.
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Journal ArticleDOI
Histone deacetylase 6 promotes growth of glioblastoma through the MKK7/JNK/c-Jun signaling pathway.
Ziyan Huang,Yong Xia,Kunhua Hu,Shulian Zeng,Liqiang Wu,Sisi Liu,Cheng Zhi,Miaoling Lai,Danmin Chen,Longchang Xie,Zhongmin Yuan +10 more
TL;DR: These findings provide new insights into the molecular mechanism of glioma malignancy regarding HDAC6 in the selective regulation of MKK7 expression and JNK/c‐Jun activity.
Journal ArticleDOI
MKK7 transcription positively or negatively regulated by SP1 and KLF5 depends on HDAC4 activity in glioma
Yezhong Wang,Yong Xia,Kunhua Hu,Minling Zeng,Cheng Zhi,Miaoling Lai,Liqiang Wu,Sisi Liu,Shulian Zeng,Ziyan Huang,Shanshan Ma,Zhongmin Yuan +11 more
TL;DR: It is reported that MKK7, not MKK4, directly activates JNK in GCs and exerts oncogenic effects on tumor formation, and suppression of both MKK8 expression and JNK/c‐Jun activities was involved in the tumor‐growth inhibitory effects induced by LMK235 in U87‐xenograft mice.
Journal ArticleDOI
Inhibition of HDAC4 Attenuated JNK/c-Jun-Dependent Neuronal Apoptosis and Early Brain Injury Following Subarachnoid Hemorrhage by Transcriptionally Suppressing MKK7.
Liqiang Wu,Shulian Zeng,Yali Cao,Ziyan Huang,Sisi Liu,Huaidong Peng,Cheng Zhi,Shanshan Ma,Kunhua Hu,Zhongmin Yuan +9 more
TL;DR: HDAC4 inhibition could be a potential alternative to prevent MKK7/JNK/c-Jun axis-mediated nervous disorders, including SAH-caused EBI, according to small interference RNAs to silence the respective HDAC members.