S
Sneha Berry
Researcher at Johns Hopkins University School of Medicine
Publications - 21
Citations - 1777
Sneha Berry is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Melanoma & Gene delivery. The author has an hindex of 11, co-authored 20 publications receiving 1379 citations. Previous affiliations of Sneha Berry include Johns Hopkins University.
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Journal ArticleDOI
PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma
Paul Nghiem,Shailender Bhatia,Evan J. Lipson,Ragini R. Kudchadkar,Natalie J. Miller,Lakshmanan Annamalai,Sneha Berry,Elliot Chartash,Adil Daud,Steven P. Fling,Philip Friedlander,Harriet M. Kluger,Holbrook E Kohrt,Lisa Lundgren,Kim Margolin,Alan Mitchell,Thomas Olencki,Drew M. Pardoll,Sunil Reddy,E. Shantha,William H. Sharfman,Elad Sharon,Lynn Shemanski,Michi M. Shinohara,Joel C. Sunshine,Janis M. Taube,John A. Thompson,John A. Thompson,Steven M. Townson,Jennifer H. Yearley,Suzanne L. Topalian,Martin A. Cheever,Martin A. Cheever +32 more
TL;DR: First-line therapy with pembrolizumab in patients with advanced Merkel-cell carcinoma was associated with an objective response rate of 56% and effectiveness was correlated with tumor viral status, as assessed by serologic and immunohistochemical testing.
Journal ArticleDOI
Melanoma subtypes demonstrate distinct PD-L1 expression profiles.
Genevieve J. Kaunitz,Tricia R. Cottrell,Mohammed Lilo,Valliammai Muthappan,Jessica Esandrio,Sneha Berry,Haiying Xu,Aleksandra Ogurtsova,Robert A. Anders,Alexander H. Fischer,Stefan Kraft,Meg R. Gerstenblith,Cheryl L. Thompson,Kord Honda,Jonathan D. Cuda,Charles G. Eberhart,James T. Handa,Evan J. Lipson,Janis M. Taube +18 more
TL;DR: PD-L1 expression in all subtypes correlated with a moderate-severe grade of CD8+ tumor-infiltrating lymphocyte (TIL) densities, supporting an adaptive mechanism of expression induced during the host antitumor response.
Journal ArticleDOI
Multidimensional, quantitative assessment of PD-1/PD-L1 expression in patients with Merkel cell carcinoma and association with response to pembrolizumab.
Nicolas A. Giraldo,Peter Nguyen,Elizabeth L. Engle,Genevieve J. Kaunitz,Tricia R. Cottrell,Sneha Berry,Benjamin Green,Abha Soni,Jonathan D. Cuda,Julie E. Stein,Joel C. Sunshine,Farah Succaria,Haiying Xu,Aleksandra Ogurtsova,Ludmila Danilova,Candice D. Church,Natalie J. Miller,Steve Fling,Lisa Lundgren,Nirasha Ramchurren,Jennifer H. Yearley,Evan J. Lipson,Mac Cheever,Robert A. Anders,Paul Nghiem,Suzanne L. Topalian,Janis M. Taube +26 more
TL;DR: It is shown that quantitative assessments of PD-1+ and PD-L1+ cell densities as well as the geographic interactions between these two cell populations correlate with clinical response.
Journal ArticleDOI
PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison.
Joel C. Sunshine,Peter Nguyen,Genevieve J. Kaunitz,Tricia R. Cottrell,Sneha Berry,Jessica Esandrio,Haiying Xu,Aleksandra Ogurtsova,Karen B. Bleich,Toby C. Cornish,Evan J. Lipson,Robert A. Anders,Janis M. Taube +12 more
TL;DR: The 5H1, SP142, 28-8, 22C3, and SP263 clones all demonstrated similar performance characteristics when used in a standardized IHC assay on melanoma specimens, and argue against the inclusion of an intensity/H-score in chromogenic PD-L1 IHC assays.
Journal ArticleDOI
Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats.
Clark Zhang,Elizabeth Nance,Panagiotis Mastorakos,Jane Chisholm,Sneha Berry,Charles G. Eberhart,Betty Tyler,Henry Brem,Jung Soo Suk,Justin Hanes +9 more
TL;DR: Development of cisplatin‐loaded nanoparticles that are small enough to move within the porous extracellular matrix between cells and that possess a dense polyethylene glycol (PEG) corona that prevents them from being trapped by adhesion as they move through the brain tumor parenchyma are described.