S
So Yoen Choi
Researcher at Korea University
Publications - 18
Citations - 751
So Yoen Choi is an academic researcher from Korea University. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 13, co-authored 17 publications receiving 603 citations. Previous affiliations of So Yoen Choi include University of Massachusetts Medical School.
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Journal ArticleDOI
C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo.
So Yoen Choi,Rodrigo Lopez-Gonzalez,Gopinath Krishnan,Hannah L. Phillips,Alissa Nana Li,William W. Seeley,Wei-Dong Yao,Sandra Almeida,Fen-Biao Gao +8 more
TL;DR: The authors generated a mouse model of C9ORF72-related amyotrophic lateral sclerosis and frontotemporal dementia based on dipeptide repeat proteins and report that defects in mitochondria may contribute to disease pathogenesis.
Journal ArticleDOI
PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility.
Jae-Ick Kim,Hye Ryeon Lee,Su Eon Sim,Jinhee Baek,Nam Kyung Yu,Jun Hyeok Choi,Hyoung Gon Ko,Yong-Seok Lee,Soowon Park,Chuljung Kwak,Sung Ji Ahn,So Yoen Choi,Hyun Kim,Kyoung-Han Kim,Peter H. Backx,Clarrisa A. Bradley,Eunjoon Kim,Deok-Jin Jang,Kyungmin Lee,Sang Jeong Kim,Sang Jeong Kim,Min Zhuo,Min Zhuo,Graham L. Collingridge,Bong-Kiun Kaang +24 more
TL;DR: It is found that PI3Kγ has a crucial and specific role in NMDA receptor (NMDAR)-mediated synaptic plasticity at mouse Schaffer collateral–commissural synapses and the impairment of NMDAR LTD by PI3kγ blockade was specifically correlated with deficits in behavioral flexibility.
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Physiological and Pathological Significance of Dynamin-Related Protein 1 (Drp1)-Dependent Mitochondrial Fission in the Nervous System
TL;DR: The recent findings about the biological importance of Drp1-mediated mitochondrial fission in neurons under physiological and pathological conditions are reviewed.
Journal ArticleDOI
(ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model of Parkinson's disease.
Tae Woo Kim,Hyo Min Cho,So Yoen Choi,Y Suguira,Takahiro Hayasaka,Mitsutoshi Setou,H C Koh,E Mi Hwang,Jae Yong Park,Shin Jung Kang,Hee-Jin Kim,Hyun Kim,Woong Sun +12 more
TL;DR: Results suggest that manipulation of PARP-1 and AMPK signaling is an effective therapeutic approach to prevent PD-related DA neurodegeneration.
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Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in C9ORF72-ALS/FTD.
Rodrigo Lopez-Gonzalez,Dejun Yang,Mochtar Pribadi,Tanya S. Kim,Gopinath Krishnan,So Yoen Choi,Soojin Lee,Giovanni Coppola,Fen-Biao Gao +8 more
TL;DR: It is found that partial inhibition of an overactivated DNA repair pathway, and of Ku80 in particular, suppresses a cell death pathway, suggesting a therapeutic approach in C9ORF72-ALS/FTD.