Woong Sun

TL;DR: A new tool for intracellular delivery of target proteins, named ‘exosomes for protein loading via optically reversible protein–protein interactions’ (EXPLORs), which is able to successfully load cargo proteins into newly generated exosomes using optogenetic control of protein-protein interactions between the cargo and an exosome-localized partner.

TL;DR: The programmed cell death of developing cells is considered an essential adaptive process that evolved to serve diverse roles and perturb (inhibit) PCD is reviewed to determine the possible repercussions for nervous system development and function.

TL;DR: The idea that clinical symptoms in the SOD1 G93A model of ALS result specifically from damage to the distal motor axon and not from activation of the death pathway is supported, and doubt is cast on the utility of anti-apoptotic therapies to combat ALS.

TL;DR: This work uniformly captures and maintains primitive neural stem cells from hESCs that can stably self-renew in the presence of leukemia inhibitory factor, GSK3 inhibitor, and TGF-β receptor inhibitor and exhibit in vivo integration.

TL;DR: It is concluded that the adrenal peripheral clock plays an essential role in harmonizing the mammalian circadian timing system by generating a robust circadian GC rhythm.