C
Catarina R. Oliveira
Researcher at University of Coimbra
Publications - 443
Citations - 25525
Catarina R. Oliveira is an academic researcher from University of Coimbra. The author has contributed to research in topics: Mitochondrion & Oxidative stress. The author has an hindex of 86, co-authored 437 publications receiving 23059 citations. Previous affiliations of Catarina R. Oliveira include Hospitais da Universidade de Coimbra & American Board of Legal Medicine.
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Journal ArticleDOI
Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
Ellen Sidransky,Mike A. Nalls,Jan O. Aasly,Judith Aharon-Peretz,Grazia Annesi,Egberto Reis Barbosa,Anat Bar-Shira,Daniela Berg,Jose Bras,Jose Bras,Alexis Brice,Alexis Brice,Chiung-Mei Chen,Lorraine N. Clark,Christel Condroyer,Elvira Valeria De Marco,Alexandra Durr,Alexandra Durr,Michael J. Eblan,Stanley Fahn,Matthew J. Farrer,Hon-Chung Fung,Ziv Gan-Or,Thomas Gasser,Ruth Gershoni-Baruch,Ruth Gershoni-Baruch,Nir Giladi,Nir Giladi,Alida Griffith,Tanya Gurevich,Tanya Gurevich,Cristina Januário,Peter Kropp,Anthony E. Lang,Guey Jen Lee-Chen,Suzanne Lesage,Karen Marder,Ignacio F. Mata,Anat Mirelman,Jun Mitsui,Ikuko Mizuta,Giuseppe Nicoletti,Giuseppe Nicoletti,Catarina R. Oliveira,Ruth Ottman,Avi Orr-Urtreger,Lygia da Veiga Pereira,Aldo Quattrone,Aldo Quattrone,Ekaterina Rogaeva,Arndt Rolfs,Hanna Rosenbaum,Roberto Rozenberg,Ali Samii,Ali Samii,Ali Samii,Ted Samaddar,Claudia Schulte,Manu Sharma,Manu Sharma,Andrew B. Singleton,Andrew B. Singleton,Mariana Spitz,Mariana Spitz,Eng-King Tan,Eng-King Tan,Nahid Tayebi,Tatsushi Toda,André R. Troiano,Shoji Tsuji,Matthias Wittstock,Tyra G. Wolfsberg,Yih-Ru Wu,Cyrus P. Zabetian,Yi Zhao,Shira G. Ziegler +75 more
TL;DR: Data collected demonstrate that there is a strong association between GBA mutations and Parkinson's disease, and those with a GBA mutation presented earlier with the disease, were more likely to have affected relatives, and were morelikely to have atypical clinical manifestations.
Journal ArticleDOI
Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease.
TL;DR: Current knowledge about the involvement of neuroinflammation in AD pathogenesis is discussed, focusing on phenotypic and functional responses of microglia, astrocytes and neurons in this process.
Journal ArticleDOI
Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: Implications for the pathogenesis of neurodegenerative diseases
TL;DR: The mitochondria have been also implicated as central executioners of cell death, and increased mitochondrial Ca2+ overload as a result of excitotoxicity has been associated with the generation of superoxide and may induce the release of proapoptotic mitochondrial proteins.
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Adenosine A2A Receptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by β-Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway
Paula M. Canas,Lisiane O. Porciúncula,Geanne M. A. Cunha,Carla G. Silva,Nuno J. Machado,Jorge M.A. Oliveira,Catarina R. Oliveira,Rodrigo A. Cunha +7 more
TL;DR: A2ARs play a crucial role in the development of Aβ-induced synaptotoxicity leading to memory dysfunction through a p38 MAPK (mitogen-activated protein kinase)-dependent pathway and provide a molecular basis for the benefits of caffeine consumption in AD.
Journal ArticleDOI
Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease.
Rosa Resende,Paula I. Moreira,Teresa Proença,Atul Deshpande,Jorge Busciglio,Cláudia Pereira,Catarina R. Oliveira +6 more
TL;DR: In this article, the authors investigated the role of oxidative stress in the early stages of Alzheimer's disease in a triple-transgenic mouse model and showed that the levels of antioxidants, namely, reduced glutathione and vitamin E, are decreased and the extent of lipid peroxidation is increased.