S
Sofia S. Villar
Researcher at University of Cambridge
Publications - 61
Citations - 1460
Sofia S. Villar is an academic researcher from University of Cambridge. The author has contributed to research in topics: Medicine & Computer science. The author has an hindex of 13, co-authored 50 publications receiving 851 citations. Previous affiliations of Sofia S. Villar include Charles III University of Madrid & Basque Center for Applied Mathematics.
Papers
More filters
Journal ArticleDOI
Adaptive designs in clinical trials: why use them, and how to run and report them
Philip Pallmann,Alun Bedding,Babak Choodari-Oskooei,Munyaradzi Dimairo,Laura Flight,Lisa V. Hampson,Lisa V. Hampson,Jane Holmes,Adrian Mander,Lang’o Odondi,Matthew R. Sydes,Sofia S. Villar,James Wason,James Wason,Christopher J. Weir,Graham M. Wheeler,Graham M. Wheeler,Christina Yap,Thomas Jaki +18 more
TL;DR: This tutorial paper provides guidance on key aspects of adaptive designs that are relevant to clinical triallists, and emphasises the general principles of transparency and reproducibility and suggest how best to put them into practice.
Journal ArticleDOI
Multi-armed Bandit Models for the Optimal Design of Clinical Trials: Benefits and Challenges.
TL;DR: In this paper, the authors proposed a bandit-based patient allocation rule that overcomes the issue of low power, thus removing a potential barrier for their use in practice, and evaluated their performance compared to other allocation rules, including fixed randomization.
Journal ArticleDOI
Multi-armed Bandit Models for the Optimal Design of Clinical Trials: Benefits and Challenges
TL;DR: In this article, the authors proposed a bandit-based patient allocation rule that overcomes the issue of low power, thus removing a potential barrier for their use in practice, and evaluated their performance compared to other allocation rules, including fixed randomization.
Journal ArticleDOI
A multicenter study of anticoagulation in operable chronic thromboembolic pulmonary hypertension.
Katherine Bunclark,Michael Newnham,Michael Newnham,Yi-Da Chiu,Yi-Da Chiu,Alessandro Ruggiero,Sofia S. Villar,Sofia S. Villar,John Cannon,Gerry Coghlan,Paul A. Corris,Luke S. Howard,David P. Jenkins,Martin Johnson,David G. Kiely,Choo Ng,Nicholas Screaton,Karen Sheares,Dolores Taboada,Steven Tsui,Stephen J. Wort,Joanna Pepke-Zaba,Mark Toshner,Mark Toshner +23 more
TL;DR: Few data exist on the safety and efficacy of vitamin K antagonists (VKAs) in CTEPH and none for direct oral anticoagulants (DOACs) in DoACs.
Journal ArticleDOI
A Bayesian adaptive design for clinical trials in rare diseases
TL;DR: A novel randomised response-adaptive design is proposed which maximises the total number of patient successes in the trial and penalises if a minimum number of patients are not recruited to each treatment arm.