G
Graham M. Wheeler
Researcher at University College London
Publications - 33
Citations - 885
Graham M. Wheeler is an academic researcher from University College London. The author has contributed to research in topics: Randomized controlled trial & Pemetrexed. The author has an hindex of 8, co-authored 31 publications receiving 519 citations. Previous affiliations of Graham M. Wheeler include Imperial College London & University of Cambridge.
Papers
More filters
Journal ArticleDOI
Adaptive designs in clinical trials: why use them, and how to run and report them
Philip Pallmann,Alun Bedding,Babak Choodari-Oskooei,Munyaradzi Dimairo,Laura Flight,Lisa V. Hampson,Lisa V. Hampson,Jane Holmes,Adrian Mander,Lang’o Odondi,Matthew R. Sydes,Sofia S. Villar,James Wason,James Wason,Christopher J. Weir,Graham M. Wheeler,Graham M. Wheeler,Christina Yap,Thomas Jaki +18 more
TL;DR: This tutorial paper provides guidance on key aspects of adaptive designs that are relevant to clinical triallists, and emphasises the general principles of transparency and reproducibility and suggest how best to put them into practice.
Journal ArticleDOI
Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP): a randomised controlled trial
Amy L Ahern,Amy L Ahern,Graham M. Wheeler,Graham M. Wheeler,Paul Aveyard,Emma Boyland,Jason C.G. Halford,Adrian Mander,Jennifer Woolston,Ann M Thomson,Melina Tsiountsioura,Darren Cole,Bethan R. Mead,Lisa Irvine,David A. Turner,Marc Suhrcke,Marc Suhrcke,Laura Pimpin,Lise Retat,Abbygail Jaccard,Laura Webber,Simon Cohn,Susan A. Jebb,Susan A. Jebb +23 more
TL;DR: For adults with overweight or obesity, referral to this open-group behavioural weight-loss programme for at least 12 weeks is more effective than brief advice and self-help materials and, although it costs more, modelling suggests that the 52-week programme is cost-effective in the longer term.
Journal ArticleDOI
Adaptive designs for dual-agent phase I dose-escalation studies
TL;DR: This work describes the methods available and discusses some of the opportunities and challenges faced in dual-agent phase I trials, as well as giving examples of trials in which adaptive designs have been implemented successfully.
Journal ArticleDOI
How to design a dose-finding study using the continual reassessment method
Graham M. Wheeler,Adrian Mander,Alun Bedding,Kristian Brock,Victoria Cornelius,Andrew P. Grieve,Thomas Jaki,Sharon Love,Sharon Love,Lang’o Odondi,Christopher J. Weir,Christina Yap,Simon Bond,Simon Bond +13 more
TL;DR: A structured framework for designing a dose-finding study using the CRM is presented and practical tools to support clinicians and statisticians, including software recommendations, and template text and tables that can be edited and inserted into a trial protocol are provided.
Journal ArticleDOI
Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs
Thomas Burnett,Pavel Mozgunov,Philip Pallmann,Sofia S. Villar,Graham M. Wheeler,Thomas Jaki,Thomas Jaki +6 more
TL;DR: The main features of adaptive designs and commonly used terminology are introduced, highlighting their utility and pitfalls, and their use is illustrated through case studies of adaptive trials ranging from early-phase dose escalation to confirmatory phase III studies.