Sofie Seghers

TL;DR: In this paper, the use of a high-pressure continuous microreactor process was considered to increase the yields and the selectivity towards the endo-isomer of cyclopentadiene and methyl acrylate.

TL;DR: In this paper, an efficient continuous-flow procedure for the synthesis of tribromomethylsulfones and tribrommethanesulfonates has been developed starting from the corresponding methylsulfone or methanesulfone and potassium hypobromite using a biphasic reaction.

TL;DR: Alameh et al. as discussed by the authors used a design-of-experiments methodology to optimize lipid-based nanoparticles to achieve high-magnitude tumor-specific CD8 T cell responses within a single round of optimization.

TL;DR: The attractive heat- and mass-transfer properties of flow technology were exploited to establish a mesoscale continuous-flow route toward lithiated methoxyallene, and an excellent conversion was obtained.

TL;DR: By applying the microwave-to-flow paradigm, a library of (α-aminoacyl)amino-substituted heterocycles was continuously produced at near quantitative conversions and the reaction was scaled up successfully and led to excellent conversions for a broad range of substrates.