Journal ArticleDOI
Efficient Continuous-Flow Bromination of Methylsulfones and Methanesulfonates and Continuous Synthesis of Hypobromite
TLDR
In this paper, an efficient continuous-flow procedure for the synthesis of tribromomethylsulfones and tribrommethanesulfonates has been developed starting from the corresponding methylsulfone or methanesulfone and potassium hypobromite using a biphasic reaction.Abstract:
An efficient continuous-flow procedure for the synthesis of tribromomethylsulfones and tribromomethanesulfonates has been developed starting from the corresponding methylsulfones or methanesulfonates and potassium hypobromite using a biphasic reaction. Two different continuous-flow systems were used and compared for the bromination reaction. Different derivatives were synthesized in excellent isolated yields in very short reaction times using a small excess of potassium hypobromite. Hypobromite can be synthesized continuously leading to the continuous production of the brominated derivates. With the optimized flow conditions, a throughput of up to 53 g/day was obtained. The bromination reaction in flow has significant advantages compared to the corresponding batch process.read more
Citations
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The Hitchhiker's Guide to Flow Chemistry
TL;DR: This review introduces readers to the basic principles and fundamentals of flow chemistry and critically discusses recent flow chemistry accounts.
Journal ArticleDOI
Taming hazardous chemistry by continuous flow technology
Marine Movsisyan,Elisabeth Delbeke,Jan Berton,Claudio Battilocchio,Steven V. Ley,Christian V. Stevens +5 more
TL;DR: This review covers some of the latest and most relevant developments in the field of continuous flow chemistry with the focus on hazardous reactions.
Journal ArticleDOI
Halogenation of organic compounds using continuous flow and microreactor technology
David Cantillo,C. Oliver Kappe +1 more
TL;DR: In this article, a continuous flow chemistry halogenation involving X2 and HX can be performed in a safe and controllable manner, using continuous flow flow chemistry (CFL).
Journal ArticleDOI
Improving the efficiency of the Diels–Alder process by using flow chemistry and zeolite catalysis
TL;DR: In this paper, the use of a high-pressure continuous microreactor process was considered to increase the yields and the selectivity towards the endo-isomer of cyclopentadiene and methyl acrylate.
Journal ArticleDOI
Safe, Selective, and High-Yielding Synthesis of Acryloyl Chloride in a Continuous-Flow System.
TL;DR: A continuous-flow methodology was developed for the fast and selective synthesis of the otherwise highly unstable acryloyl chloride, mainly important for the acrylate and polymer industry.
References
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Liquid-liquid two-phase flow patterns and mass transfer characteristics in rectangular glass microreactors
TL;DR: In this article, the shape of the interface between the immiscible liquids was controlled by a competition between the viscous forces and the local interfacial tension, and the mass transfer coefficients for parallel and slug flow were determined using instantaneous eutralisation (acidbase) reaction.
Journal ArticleDOI
Microstructured Reactors for Multiphase Reactions: State of the Art
M.N. Kashid,Lioubov Kiwi-Minsker +1 more
TL;DR: A comprehensive overview of the state-of-the-art of microstructured Reactor (MSR) applied for multiphase reactions can be found in this paper, where the authors classified the reactions based on the number of phases involved: fluid−fluid, fluid−solid, and three phase reactions.
Patent
Method of making a lithographic printing plate
TL;DR: In this paper, a light-sensitive lithographic printing plate for negative and positive images is presented, consisting of a hydrophilic support having, in succession, a light sensitive composition layer and a transparent cover film.
Journal ArticleDOI
Numbering-up and mass transfer studies of liquid-liquid two-phase microstructured reactors
TL;DR: In this paper, a capillary micro-structured reactor is numbered up for six capillaries and the mass transfer performance is investigated for various operating conditions, including interfacial tension.
Journal ArticleDOI
Highly efficient dehydration of carbohydrates to 5-(chloromethyl)furfural (CMF), 5-(hydroxymethyl)furfural (HMF) and levulinic acid by biphasic continuous flow processing
TL;DR: Using a continuous flow reactor, the dehydration of D-fructose and other carbohydrates to 5-(chloromethyl)furfural (1) is achieved in reaction times as short as 60 s as mentioned in this paper.