K
Karine Breckpot
Researcher at Vrije Universiteit Brussel
Publications - 162
Citations - 8325
Karine Breckpot is an academic researcher from Vrije Universiteit Brussel. The author has contributed to research in topics: Immunotherapy & Immune system. The author has an hindex of 49, co-authored 141 publications receiving 6687 citations. Previous affiliations of Karine Breckpot include Free University of Brussels & VU University Amsterdam.
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Journal ArticleDOI
Consensus guidelines for the detection of immunogenic cell death
Oliver Kepp,Laura Senovilla,Ilio Vitale,Erika Vacchelli,Sandy Adjemian,Patrizia Agostinis,Lionel Apetoh,Fernando Aranda,Vincenzo Barnaba,Norma Bloy,Laura Bracci,Karine Breckpot,David Brough,Aitziber Buqué,Maria G. Castro,Mara Cirone,María Isabel Colombo,Isabelle Cremer,Sandra Demaria,Luciana Dini,Aristides G. Eliopoulos,Alberto Faggioni,Silvia C. Formenti,Jitka Fucikova,Lucia Gabriele,Udo S. Gaipl,Jérôme Galon,Abhishek D. Garg,François Ghiringhelli,Nathalia A. Giese,Zong Sheng Guo,Akseli Hemminki,Martin Herrmann,James W. Hodge,Stefan Holdenrieder,Jamie Honeychurch,Hong-Min Hu,Xing Huang,Timothy M Illidge,Koji Kono,Mladen Korbelik,Dmitri V. Krysko,Sherene Loi,Pedro R. Lowenstein,Enrico Lugli,Yuting Ma,Frank Madeo,Angelo A. Manfredi,Isabelle Martins,Domenico Mavilio,Laurie Menger,Nicolò Merendino,Michael Michaud,Grégoire Mignot,Karen L. Mossman,Gabriele Multhoff,Rudolf Oehler,Fabio Palombo,Theocharis Panaretakis,Jonathan Pol,Enrico Proietti,Jean-Ehrland Ricci,Chiara Riganti,Patrizia Rovere-Querini,Anna Rubartelli,Antonella Sistigu,Mark J. Smyth,Juergen Sonnemann,Radek Spisek,John Stagg,Abdul Qader Sukkurwala,Eric Tartour,Andrew Thorburn,Stephen H. Thorne,Peter Vandenabeele,Francesca Velotti,Samuel T Workenhe,Haining Yang,Wei-Xing Zong,Laurence Zitvogel,Guido Kroemer,Lorenzo Galluzzi +81 more
TL;DR: Strategies conceived to detect surrogate markers of ICD in vitro and to screen large chemical libraries for putative I CD inducers are outlined, based on a high-content, high-throughput platform that was recently developed.
Journal ArticleDOI
Combinatorial Strategies for the Induction of Immunogenic Cell Death
Lucillia Bezu,Ligia C. Gomes-de-Silva,Heleen Dewitte,Karine Breckpot,Jitka Fucikova,Radek Spisek,Lorenzo Galluzzi,Oliver Kepp,Guido Kroemer +8 more
TL;DR: This work discusses current combinatorial approaches to convert otherwise non-immunogenic instances of RCD into bona fide ICD, and suggests that novel therapeutic regimens that trigger ICD are urgently awaited.
Journal ArticleDOI
Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death
Abhishek D. Garg,Lorenzo Galluzzi,Lionel Apetoh,Lionel Apetoh,Thaïs Baert,Raymond B. Birge,José Manuel Bravo-San Pedro,Karine Breckpot,David Brough,Ricardo A. Chaurio,Mara Cirone,An Coosemans,Pierre Coulie,Dirk De Ruysscher,Luciana Dini,Peter de Witte,Aleksandra M. Dudek-Peric,Alberto Faggioni,Jitka Fucikova,Udo S. Gaipl,Jakub Golab,Marie-Lise Gougeon,Michael R. Hamblin,Akseli Hemminki,Martin Herrmann,James W. Hodge,Oliver Kepp,Guido Kroemer,Dmitri V. Krysko,Walter Land,Frank Madeo,Angelo A. Manfredi,Stephen R. Mattarollo,Christian Maueröder,Nicolò Merendino,Gabriele Multhoff,Thomas Pabst,Jean-Ehrland Ricci,Chiara Riganti,Erminia Romano,Nicole Rufo,Mark J. Smyth,Mark J. Smyth,Jürgen Sonnemann,Radek Spisek,John Stagg,Erika Vacchelli,Peter Vandenabeele,Lien Vandenberk,Benoît Van den Eynde,Stefaan Van Gool,Francesca Velotti,Laurence Zitvogel,Patrizia Agostinis +53 more
TL;DR: The main molecular, immunological, preclinical, and clinical aspects of ICD are summarized and tabulate in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation.
Journal ArticleDOI
Lentiviral vectors in gene therapy: their current status and future potential.
TL;DR: The intention of this review is to describe the main scientific steps leading to the engineering of HIV-1 lentiviral vectors and place them in the context of current human gene therapy.
Journal ArticleDOI
Nanobody-Based Targeting of the Macrophage Mannose Receptor for Effective In Vivo Imaging of Tumor-Associated Macrophages
Kiavash Movahedi,Steve Schoonooghe,Damya Laoui,Isabelle Houbracken,Wim Waelput,Karine Breckpot,Luc Bouwens,Tony Lahoutte,Patrick De Baetselier,Geert Raes,Nick Devoogdt,Jo A. Van Ginderachter +11 more
TL;DR: These findings provide preclinical proof of concept that anti-MMR nanobodies can be used to selectively target and image TAM subpopulations in vivo, and target pro-angiogenic MMR+ TAMs.