Sonali B. Fonseca

TL;DR: This review describes recent advances in the use of CPPs for biological and therapeutic applications and describes the remarkable advancements these peptides have facilitated in cell biology.

TL;DR: A significant advance is reported in the development of mitochondrial transporters-synthetic cell-permeable peptides that are able to enter mitochondria and demonstrate that mitochondrial localization can be rationally controlled and finely tuned by altering lipophilicity and charge.

TL;DR: CTAB was identified as a potential apoptogenic quaternary ammonium compound possessing in vitro and in vivo efficacy against HNC models, and exhibited anticancer cytotoxicity against several HNC cell lines, with minimal effects on normal fibroblasts.

TL;DR: iptin, a derivative of avermectin B1 that is licensed for the treatment of the parasitic infections, strongyloidiasis and onchocerciasis, but is also effective against other worm infestations, could be rapidly advanced into clinical trial for leukemia.

TL;DR: This work reports the first successful delivery of an active DNA alkylating agent--chlorambucil--to mitochondria, and describes unexpected features that result from rerouting this drug within the cell.