S
Sook Wah Yee
Researcher at University of California, San Francisco
Publications - 106
Citations - 8837
Sook Wah Yee is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Metformin & Pharmacogenomics. The author has an hindex of 39, co-authored 92 publications receiving 7468 citations. Previous affiliations of Sook Wah Yee include Cardiff University & Georgia Regents University.
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Journal ArticleDOI
Metabolomic and Genome‐wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1
Sook Wah Yee,Marilyn M. Giacomini,Chia Hsiang Hsueh,Dietmar Weitz,Xiaomin Liang,Srijib Goswami,Jason M. Kinchen,Annabelle Coelho,Arik A. Zur,Katharina Mertsch,William Brian,Deanna L. Kroetz,Kathleen M. Giacomini +12 more
TL;DR: Conjugated bile acids and fatty acid dicarboxylates were among the metabolites discovered using both GWAS and CSA administration and future studies are needed to determine whether these metabolites can serve as qualified biomarkers for organic anion transporters.
Journal ArticleDOI
Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine.
Kathleen M. Giacomini,Sook Wah Yee,Taisei Mushiroda,Richard M. Weinshilboum,Mark J. Ratain,Michiaki Kubo +5 more
TL;DR: Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine is presented.
Journal ArticleDOI
Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).
Xiaomin Liang,Huan-Chieh Chien,Sook Wah Yee,Marilyn M. Giacomini,Eugene C. Chen,Meiling Piao,Meiling Piao,Jia Hao,Jolyn Twelves,Eve-Irene Lepist,Adrian S. Ray,Kathleen M. Giacomini +11 more
TL;DR: The data suggest that hTHTR-2 may play a role in the intestinal absorption and tissue distribution of metformin and other organic cations and that the transporter may be a target for drug-drug and drug-nutrient interactions.
Journal ArticleDOI
Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.
Swati S. More,Shuanglian Li,Sook Wah Yee,Ligong Chen,Zhidong Xu,David M. Jablons,Kathleen M. Giacomini +6 more
TL;DR: This effort aimed at the determination of the influence of organic cation transporters 1, 2, and 3 and their genetic variants on cellular uptake of picoplatin and on the individual components of the ensuing cytotoxicity such as DNA adduct formation determined that OCT1 may enhance the antitumor efficacy ofpicoplatin.
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Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1
Ji Ha Choi,Sook Wah Yee,Mee J. Kim,Loan Nguyen,Jeong Ho Lee,Ji One Kang,Stephanie Hesselson,Richard A. Castro,Doug Stryke,Susan J. Johns,Pui-Yan Kwok,Thomas E. Ferrin,Min Goo Lee,Brain L. Black,Nadav Ahituv,Kathleen M. Giacomini +15 more
TL;DR: The study suggests that the rate of transcription of MATE1 is regulated by AP-1 and AP-2rep and that a common promoter variant, g.–66T>C may affect the expression level of Mate1 in human kidney, and ultimately result in variation in drug disposition and response.