Soon Lee

TL;DR: A novel homeobox-type somatostatin transactivating factor termed STF-1 is characterized, which is uniformly expressed in cells of the endocrine pancreas and small intestine, suggesting that this protein may have a primary role in regulating peptide hormone expression and specifying endocrine cell lineage in the developing gut.

TL;DR: It is shown that long‐term exposure to alcohol causes significant impairment of HPA function in adult male Wistar rats, and multiple adaptations to stress regulatory systems may be brought about by excessive drinking, including a compromised hormonal response and a sensitized brain stress response that together contribute to dependence.

TL;DR: It is argued that amyloids have the properties required of a long-acting drug because they are stable depots that guarantee a controlled release of the active peptide drug from the amyloid termini.

TL;DR: Key amino acids, Arg-114 and Glu-761, are localized in the N- and C-cytosolic tails of VR1 that determine ligand binding and might constitute a long-suspected binding pocket.

TL;DR: Alcohol stimulates the activity of neurons in both the parvo- and the magnocellular portions of the PVN, though transcriptional activation of the CRF and VP genes in the PVNs exhibit distinct time courses, indicating that the influence of the drug is direct or is exerted through afferents to the PVn.