S
Sophie C. Cazanave
Researcher at Virginia Commonwealth University
Publications - 45
Citations - 3721
Sophie C. Cazanave is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Nonalcoholic fatty liver disease & Hepatocyte. The author has an hindex of 26, co-authored 43 publications receiving 3054 citations. Previous affiliations of Sophie C. Cazanave include French Institute of Health and Medical Research & Mayo Clinic.
Papers
More filters
Journal ArticleDOI
Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition
Michael Charlton,Anuradha Krishnan,Kimberly Viker,Schuyler O. Sanderson,Sophie C. Cazanave,Andrea L. McConico,Howard Masuoko,Gregory J. Gores +7 more
TL;DR: A diet based on high cholesterol, high saturated fat, and high fructose recapitulates features of the metabolic syndrome and NASH with progressive fibrosis represents a novel small animal model of fibrosing NASHWith high fidelity to the human condition.
Journal ArticleDOI
A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer.
Amon Asgharpour,Sophie C. Cazanave,Tommy Pacana,Mulugeta Seneshaw,Robert Vincent,Bubu A. Banini,Divya P. Kumar,Kalyani Daita,Hae Ki Min,Faridoddin Mirshahi,Pierre Bedossa,Xiaochen Sun,Yujin Hoshida,Srinivas V. Koduru,Daniel Contaifer,Urszula Osinska Warncke,Dayanjan S. Wijesinghe,Arun J. Sanyal +17 more
TL;DR: A diet-induced animal model of non-alcoholic fatty liver disease (DIAMOND) that recapitulates the key physiological, metabolic, histologic, transcriptomic and cell-signaling changes seen in humans with progressive NASH is described.
Journal ArticleDOI
Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease
TL;DR: The role of high fructose and glucose diets in contributing to organelle impairment and poor glucose transport mechanisms, which perpetuate hyperglycemia and hyperlipidemia by shunting of excess carbohydrates into lipogenesis, are discussed.
Journal ArticleDOI
Transcriptional suppression of mir‐29b‐1/mir‐29a promoter by c‐Myc, hedgehog, and NF‐kappaB
Justin L. Mott,Satoshi Kurita,Sophie C. Cazanave,Steven F. Bronk,Nathan W. Werneburg,Martin E. Fernandez-Zapico,Martin E. Fernandez-Zapico +6 more
TL;DR: In addition to c‐Myc, mir‐29 expression can be suppressed by hedgehog signaling and inflammatory pathways, both commonly activated in the genesis of human malignancies.
Journal ArticleDOI
The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids
Puneet Puri,Kalyani Daita,Andrew Joyce,Faridoddin Mirshahi,Prasanna K. Santhekadur,Sophie C. Cazanave,Velimir A. Luketic,Mohammad S. Siddiqui,Sherry Boyett,Hae-Ki Min,Divya P. Kumar,Rohit Kohli,Huiping Zhou,Phillip B. Hylemon,Melissa J. Contos,Michael O. Idowu,Arun J. Sanyal +16 more
TL;DR: NAFLD is associated with significantly altered circulating BA composition, likely unaffected by type 2 diabetes, and correlated with histological features of NASh; these observations provide the foundation for future hypothesis‐driven studies of specific effects of BAs on specific aspects of NASH.