S
Søren Holm
Researcher at University of Manchester
Publications - 431
Citations - 11522
Søren Holm is an academic researcher from University of Manchester. The author has contributed to research in topics: Health care & Research ethics. The author has an hindex of 56, co-authored 409 publications receiving 10514 citations. Previous affiliations of Søren Holm include University of Oslo & Norwegian University of Science and Technology.
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Journal ArticleDOI
MR-based automatic delineation of volumes of interest in human brain PET images using probability maps
Claus Svarer,Karine Madsen,Steen G. Hasselbalch,Lars H. Pinborg,Steven Haugbøl,Vibe G. Frokjaer,Søren Holm,Olaf B. Paulson,Gitte M. Knudsen +8 more
TL;DR: In this article, an observer-independent approach for automatic generation of volume-of-interest (VOI) brain templates to be used in emission tomography studies of the brain was developed and validated.
Journal ArticleDOI
A 15O-H2O PET study of meditation and the resting state of normal consciousness
TL;DR: It is concluded that the H215O PET method may measure CBF distribution in the meditative state as well as during the resting state of normal consciousness, and that characteristic patterns of neural activity support each state.
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Persistent Resetting of the Cerebral Oxygen/Glucose Uptake Ratio by Brain Activation: Evidence Obtained with the Kety—Schmidt Technique
Peter Lund Madsen,Steen G. Hasselbalch,Lars P. Hagemann,Karsten Skovgaard Olsen,Jens Bülow,Søren Holm,Gordon Wildschiødtz,Olaf B. Paulson,Niels A. Lassen +8 more
TL;DR: Measurements confirm earlier reports that brain activation can induce resetting of the cerebral oxygen/glucose consumption ratio, and indicate that the resetting persists for a long period after cerebral activation has been terminated and physiologic stress indicators returned to baseline values.
Journal ArticleDOI
Cerebral O2 metabolism and cerebral blood flow in humans during deep and rapid-eye-movement sleep
Peter Lund Madsen,Jes F. Schmidt,Gordon Wildschiødtz,Lars Friberg,Søren Holm,S. Vorstrup,Niels A. Lassen +6 more
TL;DR: A deep-sleep-associated statistically highly significant 25% decrease in CMRO2 is found, a magnitude of depression according with studies of glucose uptake and reaching levels otherwise associated with light anesthesia.
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Regional differences in the CBF and BOLD responses to hypercapnia: a combined PET and fMRI study.
Egill Rostrup,Ian Law,Morten Blinkenberg,Henrik Larsson,Alfred Peter Born,Søren Holm,Olaf B. Paulson +6 more
TL;DR: It was concluded that the differences in the magnitude of the fMRI response can largely be attributed to differences in flow and that there is a considerable difference in the time course of the response between gray and white matter.