S
Souad R. Sennoune
Researcher at Texas Tech University Health Sciences Center
Publications - 35
Citations - 1133
Souad R. Sennoune is an academic researcher from Texas Tech University Health Sciences Center. The author has contributed to research in topics: Cancer cell & Intracellular pH. The author has an hindex of 14, co-authored 33 publications receiving 969 citations.
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Journal ArticleDOI
Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity
Souad R. Sennoune,Karina Bakunts,Gloria M. Martinez,Jenny L. Chua-Tuan,Yamina Kebir,Mohamed Attaya,Raul Martinez-Zaguilan +6 more
TL;DR: Data indicate that V-ATPases located at the plasma membrane are involved in the acquisition of a more metastatic phenotype, as well as decreasing the invasion and migration in the highly metastatic cells.
Journal ArticleDOI
Plasmalemmal vacuolar-type H+-ATPase in cancer biology.
TL;DR: The V-ATPases have been involved in regulation of extracellular acidity, essential for cellular invasiveness and proliferation in tumor metastasis, and its role in cancer biology is discussed.
Journal ArticleDOI
AFM nano-mechanics and calcium dynamics of prostate cancer cells with distinct metastatic potential.
Lyndon D. Bastatas,Dalia Martinez-Marin,James Matthews,Jood Hashem,Yong Joong Lee,Souad R. Sennoune,Stephanie Filleur,Raul Martinez-Zaguilan,Soyeun Park +8 more
TL;DR: Although the suppressed mechanical compliance of highly metastatic cells may not support the enhanced cancer metastasis, the enhanced adhesion and calcium dynamics are favorable for invasion and extra-vasation required for malignant progression.
Journal ArticleDOI
Vacuolar-type H+-ATPases at the plasma membrane regulate pH and cell migration in microvascular endothelial cells
Jose D. Rojas,Souad R. Sennoune,Debasish Maiti,Karina Bakunts,M. Reuveni,Shankar C. Sanka,Gloria M. Martinez,Elisabeth A. Seftor,Cynthia J. Meininger,Guoyao Wu,David E. Wesson,Mary J.C. Hendrix,Raul Martinez-Zaguilan +12 more
TL;DR: It is hypothesized that the presence of plasmalemmal vacuolar-type proton ATPases (pmV-ATPases) allows microvascular endothelial cells to better cope with this acidic environment and that pmV- ATPases are required for cell migration.
Journal ArticleDOI
Porphyrin Immobilized Nanographene Oxide for Enhanced and Targeted Photothermal Therapy of Brain Cancer
Siheng Su,Jilong Wang,Evan Vargas,Junhua Wei,Raul Martinez-Zaguilan,Souad R. Sennoune,Michelle L. Pantoya,Shiren Wang,Jharna Chaudhuri,Jingjing Qiu +9 more
TL;DR: Porphyrin immobilized nanographene oxide was synthesized and bioconjugated with a peptide to achieve enhanced and targeted photothermal therapy for brain cancer and completely eliminated the tumor in vivo.