S
Sri Rajasekhar Kothapalli
Researcher at Pennsylvania State University
Publications - 96
Citations - 2382
Sri Rajasekhar Kothapalli is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Imaging phantom & Ultrasound. The author has an hindex of 22, co-authored 86 publications receiving 1856 citations. Previous affiliations of Sri Rajasekhar Kothapalli include Stanford University & University of Michigan.
Papers
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Journal ArticleDOI
Activatable Oligomerizable Imaging Agents for Photoacoustic Imaging of Furin-Like Activity in Living Subjects
Anca Dragulescu-Andrasi,Sri Rajasekhar Kothapalli,Grigory Tikhomirov,Jianghong Rao,Sanjiv S. Gambhir +4 more
TL;DR: A molecular probe, which upon proteolytic processing is retained at the site of enzyme activity and provides PA contrast and could report enzyme activity in living subjects at depths significantly greater than fluorescence imaging probes and has potential for molecular imaging in deep tumors.
Journal ArticleDOI
Design, synthesis, and imaging of an activatable photoacoustic probe.
Jelena Levi,Sri Rajasekhar Kothapalli,Te Jen Ma,Keith B. Hartman,Butrus T. Khuri-Yakub,Sanjiv S. Gambhir +5 more
TL;DR: The design, synthesis, and evaluation of an activatable probe shows great promise for enabling detection of the cleaved probe in the presence of high levels of nonactivated, uncleaved probe, a difficult task to attain in absorbance-based modality.
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Construction and validation of nano gold tripods for molecular imaging of living subjects.
Kai Cheng,Sri Rajasekhar Kothapalli,Hongguang Liu,Ai Leen Koh,Jesse V. Jokerst,Han Jiang,Meng Yang,Jinbo Li,Jelena Levi,Joseph C. Wu,Sanjiv S. Gambhir,Zhen Cheng +11 more
TL;DR: This study suggests that Au-tripods can be reliably synthesized through stringently controlled chemical synthesis and could serve as a new generation of platform with high selectivity and sensitivity for multimodality molecular imaging.
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Intraoperative Pancreatic Cancer Detection using Tumor-Specific Multimodality Molecular Imaging
Willemieke S. Tummers,Willemieke S. Tummers,Sarah E. Miller,Nutte Teraphongphom,Adam J. Gomez,Idan Steinberg,David M. Huland,Steve Hong,Sri Rajasekhar Kothapalli,Alifia Hasan,Robert Ertsey,Bert A. Bonsing,Alexander L. Vahrmeijer,Rutger-Jan Swijnenburg,Teri A. Longacre,George A. Fisher,Sanjiv S. Gambhir,George A. Poultsides,Eben L. Rosenthal +18 more
TL;DR: The safety and feasibilty of intraoperative, tumor-specific detection of PDAC using cetuximab-IRDye800 with multimodal molecular imaging of the primary tumor and metastases was demonstrated.
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Development and application of stable phantoms for the evaluation of photoacoustic imaging instruments.
Sarah E. Bohndiek,Sandhya Bodapati,Dominique Van de Sompel,Sri Rajasekhar Kothapalli,Sanjiv S. Gambhir +4 more
TL;DR: This work developed a protocol for fabrication of physical phantoms for photoacoustic imaging from polyvinyl chloride plastisol (PVCP), and created specific designs to enable routine quality control; the testing of robustness of photoac acoustic signals as a function of background; and the evaluation of the maximum imaging depth available.