Srinivas Mutalik

TL;DR: The results of dissolution studies indicated that formulation F-I (drug-to-HPMC, 1∶4; ethanol as granulating agent) could extend the drug release up to 24 hours, and the mechanism of drug release from F-IX was diffusion coupled with erosion.

TL;DR: The transdermal patches containing glibenclamide prevented the severe hypoglycemia in the initial hours and could maintain almost steady-state concentration of drug within the pharmacologically effective range for prolonged period of time, according to the pharmacokinetic evaluation.

TL;DR: The optimized transfersomes were found to increase the cell viability and reduce the lipid peroxidation, intracellular ROS and expression of MMPs in HaCaT cells, which underline the potential application of the developed transfersomes in sunscreen cream/lotions for improvement of UV radiation-protection along with deriving antioxidant and anti-aging effects.

TL;DR: The primary skin irritation and skin histopathology study indicated that the prepared IPN membranes were less irritant and safe for skin application.

TL;DR: P pH-responsive interpenetrating network (IPN) hydrogel beads of polyacrylamide grafted κ-carrageenan and sodium alginate for targeting ketoprofen to the intestine indicated that the prepared beads were able to retard the drug release in stomach leading to the reduced ulceration, hemorrhage and erosion of gastric mucosa.