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Stacey Shiovitz
Researcher at University of Washington
Publications - 11
Citations - 735
Stacey Shiovitz is an academic researcher from University of Washington. The author has contributed to research in topics: Breast cancer & Population. The author has an hindex of 8, co-authored 11 publications receiving 602 citations. Previous affiliations of Stacey Shiovitz include Fred Hutchinson Cancer Research Center & University of Michigan.
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Journal ArticleDOI
Genetics of breast cancer: a topic in evolution
TL;DR: Investigation of common, low-penetrance alleles contributing to risk in a polygenic fashion has yielded a small number of suggestive single-nucleotide polymorphisms, but the contributive risk of an individual SNP is quite small.
Journal ArticleDOI
Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population
Avraham Shaag,Tom Walsh,Paul Renbaum,Tomas Kirchhoff,Khedoudja Nafa,Stacey Shiovitz,Jessica B. Mandell,Piri Welcsh,Ming K. Lee,Nathan A. Ellis,Kenneth Offit,Ephrat Levy-Lahad,Mary Claire King +12 more
TL;DR: The results suggest that selecting probands with extended haplotypes that co-segregate with disease can improve the efficiency of resequencing efforts and that quantitative complementation tests in yeast can be used to evaluate variants in genes with highly conserved function.
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Molecular phenotypes of colorectal cancer and potential clinical applications.
TL;DR: Four tumor markers that have been widely studied as reflections of CRC heterogeneity are described: (i) microsatellite instability (MSI) or DNA mismatch repair (MMR) deficiency, (ii) the CpG island methylator phenotype (CIMP), and somatic mutations in BRAF and KRAS.
Journal ArticleDOI
CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer.
Stacey Shiovitz,Stacey Shiovitz,Monica M. Bertagnolli,Lindsay A. Renfro,Eun Mi Nam,Nathan R. Foster,Slavomir Dzieciatkowski,Yanxin Luo,Yanxin Luo,Victoria Valinluck Lao,Victoria Valinluck Lao,Raymond J. Monnat,Mary J. Emond,Nancy Maizels,Donna Niedzwiecki,Richard M. Goldberg,Leonard B. Saltz,Alan P. Venook,Robert S. Warren,William M. Grady,William M. Grady +20 more
TL;DR: Patients with stage III, CIMP-positive, MMR-intact colon tumors have longer survival times when irinotecan is added to combination therapy with fluorouracil and leucovorin.
Journal ArticleDOI
Characterisation of Familial Colorectal Cancer Type X, Lynch syndrome, and non-familial colorectal cancer
Stacey Shiovitz,Stacey Shiovitz,Wade Copeland,Michael N. Passarelli,Andrea N. Burnett-Hartman,Andrea N. Burnett-Hartman,William M. Grady,William M. Grady,John D. Potter,John D. Potter,John D. Potter,Steve Gallinger,Daniel D. Buchanan,Daniel D. Buchanan,Christophe Rosty,Christophe Rosty,Aung Ko Win,Mark A. Jenkins,S. N. Thibodeau,Robert W. Haile,John A. Baron,Loic Le Marchand,Polly A. Newcomb,Polly A. Newcomb,N. M. Lindor +24 more
TL;DR: FCCTX were less likely to be current tobacco users; other exposures were similar between these groups; Histopathologic differences highly suggestive of LS CRCs do not appear to be shared by FCCTX.