S
Stefan Hohmann
Researcher at Chalmers University of Technology
Publications - 205
Citations - 16932
Stefan Hohmann is an academic researcher from Chalmers University of Technology. The author has contributed to research in topics: Saccharomyces cerevisiae & Osmotic shock. The author has an hindex of 62, co-authored 204 publications receiving 15988 citations. Previous affiliations of Stefan Hohmann include University of the Free State & Technische Universität Darmstadt.
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Substrate activation of brewers' yeast pyruvate decarboxylase is abolished by mutation of cysteine 221 to serine.
Irina Baburina,Yuhong Gao,Zhixiang Hu,Frank Jordan,Stefan Hohmann,William Furey,William Furey +6 more
TL;DR: Brewers' yeast pyruvate decarboxylase, a thiamin diphosphate and Mg(II)-dependent enzyme, isolated from Saccharomyces cerevisiae possesses four cysteines/subunit at positions 69, 152, 221, and 222, and it is clearly shown that the mutation at C221, but not at C222, leads to abolished substrate activation.
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Nonsense suppressors partially revert the decrease of the mRNA level of a nonsense mutant allele in yeast.
Daniel Gozalbo,Stefan Hohmann +1 more
TL;DR: Suc2° is a naturally occurring amber mutant allele of the yeast invertase structural gene SUC2, which allows suc2° strains to ferment sucrose and causes an increase of the SUC-specific mRNA level.
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Conditional Osmotic Stress in Yeast. A system to study transport through aquaglyceroporins and osmostress signaling
Sara Karlgren,Nina Pettersson,Bodil Nordlander,John C. Mathai,Jeffrey L. Brodsky,Mark L. Zeidel,Roslyn M. Bill,Stefan Hohmann +7 more
TL;DR: In this paper, the inability of the Saccharomyces cerevisiae gpd1Δ gpd2Δ mutant to produce glycerol and to adapt to high osmolarity was investigated.
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Rewiring yeast osmostress signalling through the MAPK network reveals essential and non-essential roles of Hog1 in osmoadaptation
TL;DR: It is revealed that osmotic up-regulation of only two Hog1-dependent glycerol biosynthesis genes, GPD1 and GPP2, is sufficient for successful osmoadaptation and that knockout approaches may lead to over-interpretation of phenotypic data.
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Implications of FPS1 deletion and membrane ergosterol content for glycerol efflux from Saccharomyces cerevisiae.
Tze Hsien Toh,Gerald Kayingo,Marthinus J. van der Merwe,Stephanus G. Kilian,John E. Hallsworth,Stefan Hohmann,Bernard A. Prior +6 more
TL;DR: Ergosterol supplementation was shown to partially suppress the hypo-osmotic sensitivity phenotype of the fps1delta strain, leading to more efficient glycerol efflux, and improved survival, and the results obtained suggest that a higher ergosterol content facilitates the flux of Glycerol across the plasma membrane of S. cerevisiae cells.