R
Roslyn M. Bill
Researcher at Aston University
Publications - 138
Citations - 5707
Roslyn M. Bill is an academic researcher from Aston University. The author has contributed to research in topics: Membrane protein & Pichia pastoris. The author has an hindex of 39, co-authored 127 publications receiving 4364 citations. Previous affiliations of Roslyn M. Bill include John Radcliffe Hospital & Imperial College London.
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Journal ArticleDOI
Overcoming barriers to membrane protein structure determination
Roslyn M. Bill,Peter J. F. Henderson,So Iwata,Edmund R.S. Kunji,Hartmut Michel,Richard Neutze,Simon Newstead,Berend Poolman,Christopher G. Tate,Horst Vogel +9 more
TL;DR: Rational approaches to overcoming the bottlenecks in the field are urgently required as membrane proteins, which typically comprise ∼30% of the proteomes of organisms, are dramatically under-represented in the structural database of the Protein Data Bank.
Journal ArticleDOI
Human aquaporins : regulators of transcellular water flow
Rebecca E. Day,Philip Kitchen,David Owen,Charlotte E. Bland,Lindsay Marshall,Alex C. Conner,Roslyn M. Bill,Matthew T. Conner +7 more
TL;DR: This review examines the regulatory role of AQPs in transcellular water flow, especially in CVR, and focuses on key systems of the human body, encompassing processes as diverse as urine concentration in the kidney to clearance of brain oedema.
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Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema
Philip Kitchen,Mootaz M. Salman,Mootaz M. Salman,Mootaz M. Salman,Andrea M. Halsey,Charlotte Clarke-Bland,Justin A. MacDonald,Hiroaki Ishida,Hans J. Vogel,Sharif Almutiri,Sharif Almutiri,Ann Logan,Stefan Kreida,Tamim Al-Jubair,Julie Winkel Missel,Pontus Gourdon,Pontus Gourdon,Susanna Törnroth-Horsefield,Matthew T. Conner,Zubair Ahmed,Alex C. Conner,Roslyn M. Bill +21 more
TL;DR: It is shown that AQP4 cell-surface abundance increases in response to hypoxia-induced cell swelling in a calmodulin-dependent manner, and it is proposed that targeting the mechanism of cal modulin-mediated cell- surface localization of AQP 4 is a viable strategy for development of CNS edema therapies.
Journal ArticleDOI
Switching the mode of metabolism in the yeast Saccharomyces cerevisiae
Karin Otterstedt,Christer Larsson,Roslyn M. Bill,Anders Ståhlberg,Eckhard Boles,Stefan Hohmann,Lena Gustafsson +6 more
TL;DR: An S. cerevisiae strain is generated in which glucose uptake is dependent on a chimeric hexose transporter mediating reduced sugar uptake, and shows a fully respiratory metabolism also at high glucose levels, illustrating that manipulating a single step can alter the mode of metabolism.
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G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent
Mohammed Jamshad,Jack Charlton,Yu-pin Lin,Sarah J Routledge,Zharain Bawa,Timothy J. Knowles,Michael Overduin,Niek Dekker,Timothy R. Dafforn,Roslyn M. Bill,David R. Poyner,Mark Wheatley +11 more
TL;DR: The first solubilization and purification of a functional GPCR [human adenosine A2A receptor (A2AR)], in the total absence of detergent at any stage, is reported, by exploiting spontaneous encapsulation by styrene maleic acid co-polymer direct from the membrane into a nanoscale SMA lipid particle (SMALP).