scispace - formally typeset
S

Stefan Karlsson

Researcher at Lund University

Publications -  303
Citations -  20537

Stefan Karlsson is an academic researcher from Lund University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 70, co-authored 292 publications receiving 19180 citations. Previous affiliations of Stefan Karlsson include deCODE genetics & Netherlands Cancer Institute.

Papers
More filters
Journal ArticleDOI

A Novel Mouse Model for RPS19-Deficient Diamond-Blackfan Anemia Locates the Erythroid Defect at CFU-E/Proerythroblast Transition

Pekka Jaako, +7 more
- 20 Nov 2009 - 
TL;DR: Two novel mouse models for RPS19-deficient DBA that recapitulate the key erythroid phenotype seen in patients are generated and characterized, revealing a profound decrease in the number of proerythroblasts, while the levels of erythyroid and bipotential megakaryocytic-erythoid progenitors were normal or increased.
Journal ArticleDOI

Connecting ribosomes with bone marrow failure

Stefan Karlsson
- 01 Sep 2007 - 
TL;DR: The SBDS protein, defective in Schwachman-Diamond syndrome (SDS), associates with the 60S ribosomal subunit and the 28S Ribosomal RNA; mutations in SBDS most likely cause abnormal ribosome biogenesis.
Journal ArticleDOI

Bone Marrow Failure in RPS19-Deficient Mice Is Partly Caused by p53 Activation and Responds to L-Leucine Treatment

Pekka Jaako, +4 more
- 18 Nov 2011 - 
TL;DR: A key role of p53 activation in RPS19-deficient DBA is demonstrated and the preliminary data supports the role of L-leucine as a therapeutic agent in the treatment of DBA and suggests that p53-independent pathways may contribute towards phenotype upon severe RPS 19 deficiency.
Journal ArticleDOI

GLO polymorphism in Iceland.

Stefan Karlsson, +2 more
- 01 Jan 1980 - 
TL;DR: The phenotypes of red cell glyoxalase I (GLO) were determined in two Icelandic population samples using starch-gel electrophoresis and high-voltage agarose-gel electrification and in a group of Icelandic insulin-dependent diabetics the gene frequencies were found to be very similar.
Journal ArticleDOI

Locus-Control-Region-Coupled Beta (S)(Antilles)- and Alpha(2)-Hemoglobin Genes Select for High Alpha(2)-Hemoglobin Expression in Adult Transgenic Mice

Frank E. Shafer, +9 more
- 01 Jun 1994 - 
TL;DR: The results support a reciprocally competitive model for LCR-hemoglobin developmental switching and demonstrate that if the &mgr;LCR is coupled to the beta(S)(Antilles)- and alpha(2)-hemoglobin genes in tandem, only the distalalpha(2)hemoglobin gene is selected for expression to significant levels in adult mice.