Stefan M. Noha

TL;DR: Honokiol is identified as a partial non-adipogenic PPARγ agonist in vitro which prevented hyperglycemia and weight gain in vivo and provides a molecular explanation for the use of Magnolia in traditional medicine.

TL;DR: In this article, the authors used a combination of in silico, in vitro, cell-based and in vivo models to identify and validate natural products as promising leads for partial novel PPARγ activators.

TL;DR: Embelin potently suppressed the biosynthesis of eicosanoids by selective inhibition of 5-LO and mPGES-1 with IC₅₀=0.06 and 0.2 μM, which suggests embelin as novel chemotype for development of dual 5- LO/mPGes-1 inhibitors.

TL;DR: These findings provide further evidence of the anti-inflammatory potential of frankincense preparations and reveal novel, potent bioactivities of tirucallic acids, roburic acids, and lupeolic acids.

TL;DR: The characterization of the natural product plumericin as a highly potent inhibitor of the NF‐κB pathway with a novel chemical scaffold, which was isolated from extracts of Himatanthus sucuuba, an Amazonian plant traditionally used to treat inflammation‐related disorders is reported.