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Elke H. Heiss
Researcher at University of Vienna
Publications - 133
Citations - 7903
Elke H. Heiss is an academic researcher from University of Vienna. The author has contributed to research in topics: Vascular smooth muscle & Chemistry. The author has an hindex of 38, co-authored 123 publications receiving 6557 citations. Previous affiliations of Elke H. Heiss include University of Innsbruck & Dartmouth College.
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Journal ArticleDOI
Discovery and resupply of pharmacologically active plant-derived natural products: A review.
Atanas G. Atanasov,Birgit Waltenberger,Eva-Maria Pferschy-Wenzig,Thomas Linder,Christoph Wawrosch,Pavel Uhrin,Veronika Temml,Limei Wang,Stefan Schwaiger,Elke H. Heiss,Judith M. Rollinger,Judith M. Rollinger,Daniela Schuster,Johannes M. Breuss,Valery N. Bochkov,Marko D. Mihovilovic,Brigitte Kopp,Rudolf Bauer,Verena M. Dirsch,Hermann Stuppner +19 more
TL;DR: While the intrinsic complexity of natural product-based drug discovery necessitates highly integrated interdisciplinary approaches, the reviewed scientific developments, recent technological advances, and research trends clearly indicate that natural products will be among the most important sources of new drugs in the future.
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Nuclear Factor κB Is a Molecular Target for Sulforaphane-mediated Anti-inflammatory Mechanisms
TL;DR: A potent decrease in lipopolysaccharide (LPS)-induced secretion of pro-inflammatory and pro-carcinogenic signaling factors in cultured Raw 264.7 macrophages after SFN treatment is reported, providing novel evidence that anti-inflammatory mechanisms contribute to sulforaphane-mediated cancer chemoprevention.
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Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review.
Limei Wang,Birgit Waltenberger,Eva-Maria Pferschy-Wenzig,Martina Blunder,Xin Liu,Clemens Malainer,Tina Blazevic,Stefan Schwaiger,Judith M. Rollinger,Elke H. Heiss,Daniela Schuster,Brigitte Kopp,Rudolf Bauer,Hermann Stuppner,Verena M. Dirsch,Atanas G. Atanasov +15 more
TL;DR: A significant research effort has recently been undertaken to explore the PPARγ-activating potential of a wide range of natural products originating from traditionally used medicinal plants or dietary sources.
Journal Article
Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop.
Clarissa Gerhäuser,Axel Alt,Elke H. Heiss,Amira M. Gamal-Eldeen,Karin Klimo,Jutta Knauft,Isabell Neumann,Hans-Rudolf Scherf,Norbert Frank,Helmut Bartsch,Hans Becker +10 more
TL;DR: Together, the data provide evidence for the potential application of XN as a novel, readily available chemopreventive agent, and clinical investigations are warranted once efficacy and safety in animal models have been established.
Journal ArticleDOI
Mechanism-based in vitro screening of potential cancer chemopreventive agents
Clarissa Gerhäuser,Karin Klimo,Elke H. Heiss,Isabell Neumann,Amira M. Gamal-Eldeen,Jutta Knauft,Guang-Yaw Liu,Somkid Sitthimonchai,Norbert Frank +8 more
TL;DR: A battery of cell- and enzyme-based in vitro marker systems relevant for prevention of carcinogenesis in vivo are set up, and the usefulness of the approach could be demonstrated by identification of hitherto unknown mechanisms of selected agents.