S
Stefania Di Marco
Researcher at Merck & Co.
Publications - 36
Citations - 4000
Stefania Di Marco is an academic researcher from Merck & Co.. The author has contributed to research in topics: Hepatitis C virus & Protein structure. The author has an hindex of 27, co-authored 35 publications receiving 3763 citations. Previous affiliations of Stefania Di Marco include Novartis.
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Journal ArticleDOI
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor
Alessandro Vannini,Cinzia Volpari,Gessica Filocamo,Elena Caroli Casavola,Mirko Brunetti,Debora Renzoni,Prasun K. Chakravarty,Chantal Paolini,Raffaele De Francesco,Paola Gallinari,Christian Steinkühler,Stefania Di Marco +11 more
TL;DR: The crystal structure of human HDAC8 in complex with a hydroxamic acid inhibitor is reported, indicating the importance of this HDAC subtype for tumor cell proliferation and a direct role of potassium in the fold stabilization ofHDAC8.
Journal ArticleDOI
HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics.
TL;DR: Since these processes are affected by malignant transformation, HDAC inhibitors were developed as antineoplastic drugs and are showing encouraging efficacy in cancer patients.
Journal ArticleDOI
The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA
Alessandro Vannini,Cinzia Volpari,Cesare Gargioli,Ester Muraglia,Riccardo Cortese,Raffaele De Francesco,Petra Neddermann,Stefania Di Marco +7 more
TL;DR: The crystal structure of TraR, the transcriptional regulator involved in quorum sensing of Agrobacterium tumefaciens, is determined and reveals an asymmetric homodimer, with one monomer longer than the other.
Journal ArticleDOI
A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA
Katie J. Ewer,Tommy Rampling,N Venkatraman,Georgina Bowyer,Daniel B. Wright,Teresa Lambe,Egeruan B. Imoukhuede,Ruth O. Payne,Sarah Katharina Fehling,Thomas Strecker,Nadine Biedenkopf,Verena Krähling,Claire M. Tully,Nick J. Edwards,Emma M. Bentley,Dhanraj Samuel,Geneviève M. Labbé,Jing Jin,Malick M. Gibani,Alice Minhinnick,Morven Wilkie,Ian D. Poulton,Natalie Lella,Rachel Roberts,Felicity Hartnell,Carly M. Bliss,Kailan Sierra-Davidson,Jonathan Powlson,Eleanor Berrie,Richard S. Tedder,François Roman,Iris De Ryck,Alfredo Nicosia,Nancy J. Sullivan,Daphne A. Stanley,Olivier Tshiani Mbaya,Julie E. Ledgerwood,Richard M. Schwartz,Loredana Siani,Stefano Colloca,Antonella Folgori,Stefania Di Marco,Riccardo Cortese,Edward Wright,Stephan Becker,Barney S. Graham,Richard A. Koup,Myron M. Levine,Ariane Volkmann,Paul Chaplin,Andrew J. Pollard,Simon J. Draper,W. Ripley Ballou,Alison M. Lawrie,Sarah C. Gilbert,Adrian V. S. Hill +55 more
TL;DR: The chimpanzee adenovirus 3 (ChAd3) vaccine boosted with MVA elicited B-cell and T-cell immune responses to ZEBOV that were superior to those induced by the ChAd3 vaccine alone.
Journal ArticleDOI
Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone.
Peer R. E. Mittl,Stefania Di Marco,Joseph F. Krebs,Xu Bai,Donald S. Karanewsky,John P. Priestle,Kevin J. Tomaselli,Markus G. Grütter +7 more
TL;DR: The cysteine protease CPP32 has been expressed in a soluble form in Escherichia coli and purified to >95% purity, and the overall topology is very similar to that of interleukin-1β-converting enzyme (ICE); however, differences exist at the N terminus of the p17 subunit.