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Alessandro Vannini
Researcher at Institute of Cancer Research
Publications - 52
Citations - 3193
Alessandro Vannini is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: RNA polymerase II & RNA polymerase III. The author has an hindex of 20, co-authored 49 publications receiving 2732 citations. Previous affiliations of Alessandro Vannini include Sapienza University of Rome & Roma Tre University.
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Journal ArticleDOI
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor
Alessandro Vannini,Cinzia Volpari,Gessica Filocamo,Elena Caroli Casavola,Mirko Brunetti,Debora Renzoni,Prasun K. Chakravarty,Chantal Paolini,Raffaele De Francesco,Paola Gallinari,Christian Steinkühler,Stefania Di Marco +11 more
TL;DR: The crystal structure of human HDAC8 in complex with a hydroxamic acid inhibitor is reported, indicating the importance of this HDAC subtype for tumor cell proliferation and a direct role of potassium in the fold stabilization ofHDAC8.
Journal ArticleDOI
Conservation between the RNA Polymerase I, II, and III Transcription Initiation Machineries
TL;DR: The similarities and differences between the three eukaryotic transcription machineries are outlined, including the conserved core initiation complex that stabilizes the open DNA promoter complex and directs initial RNA synthesis.
Journal ArticleDOI
The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA
Alessandro Vannini,Cinzia Volpari,Cesare Gargioli,Ester Muraglia,Riccardo Cortese,Raffaele De Francesco,Petra Neddermann,Stefania Di Marco +7 more
TL;DR: The crystal structure of TraR, the transcriptional regulator involved in quorum sensing of Agrobacterium tumefaciens, is determined and reveals an asymmetric homodimer, with one monomer longer than the other.
Journal ArticleDOI
Structure of eukaryotic RNA polymerases.
Patrick Cramer,Karim-Jean Armache,Sonja Baumli,Stefan Benkert,Florian Brueckner,Claudia Buchen,Gerke E. Damsma,Stefan Dengl,Sebastian R. Geiger,Anja J. Jasiak,Anass Jawhari,Stefan Jennebach,Tomislav Kamenski,Hubert Kettenberger,Claus-D. Kuhn,Elisabeth Lehmann,Kristin Leike,Jasmin F. Sydow,Alessandro Vannini +18 more
TL;DR: A catalog of available structural information for Pol I, Pol II, and Pol III is provided, which showed that the active center region and core enzymes are similar to Pol II and that strong structural differences on the surfaces account for gene class-specific functions.
Journal ArticleDOI
Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex.
Alessandro Vannini,Cinzia Volpari,Paola Gallinari,Philip Jones,Marco Mattu,Andrea Carfi,Raffaele De Francesco,Christian Steinkühler,Stefania Di Marco +8 more
TL;DR: The structure clarifies the role of active‐ site residues in the deacetylation reaction and substrate recognition and shows the unexpected role of a conserved residue at the active‐site rim, Asp 101, in positioning the substrate by directly interacting with the peptidic backbone and imposing a constrained cis‐conformation.