C
Christian Steinkühler
Researcher at Merck & Co.
Publications - 130
Citations - 8082
Christian Steinkühler is an academic researcher from Merck & Co.. The author has contributed to research in topics: NS3 & Protease. The author has an hindex of 46, co-authored 125 publications receiving 7582 citations. Previous affiliations of Christian Steinkühler include University of Rome Tor Vergata & Schering-Plough.
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Journal ArticleDOI
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor
Alessandro Vannini,Cinzia Volpari,Gessica Filocamo,Elena Caroli Casavola,Mirko Brunetti,Debora Renzoni,Prasun K. Chakravarty,Chantal Paolini,Raffaele De Francesco,Paola Gallinari,Christian Steinkühler,Stefania Di Marco +11 more
TL;DR: The crystal structure of human HDAC8 in complex with a hydroxamic acid inhibitor is reported, indicating the importance of this HDAC subtype for tumor cell proliferation and a direct role of potassium in the fold stabilization ofHDAC8.
Journal ArticleDOI
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.
Armin Lahm,Chantal Paolini,Michele Pallaoro,Maria Chiara Nardi,Philip Jones,Petra Neddermann,Sonia Sambucini,Matthew J. Bottomley,P. Lo Surdo,Andrea Carfi,Uwe Koch,R. De Francesco,Christian Steinkühler,Paola Gallinari +13 more
TL;DR: Evidence is presented supporting the view that vertebrate class IIa HDACs may have evolved to maintain low basal activities on acetyl-lysines and to efficiently process restricted sets of specific, still undiscovered natural substrates.
Journal ArticleDOI
HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics.
TL;DR: Since these processes are affected by malignant transformation, HDAC inhibitors were developed as antineoplastic drugs and are showing encouraging efficacy in cancer patients.
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Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors.
Giulia Minetti,Claudia Colussi,Raffaella Adami,Carlo Serra,Chiara Mozzetta,Valeria Parente,S Fortuni,Stefania Straino,Maurilio Sampaolesi,M Di Padova,Barbara Illi,Paola Gallinari,Christian Steinkühler,Maurizio C. Capogrossi,Vittorio Sartorelli,Roberto Bottinelli,Carlo Gaetano,Pier Lorenzo Puri +17 more
TL;DR: It is shown that deacetylase inhibitors increase the size of myofibers in dystrophin-deficient and α-sarcoglycan–deficient mice by inducing the expression of the myostatin antagonist follistatin in satellite cells.
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Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation
Gianluca Canettieri,Lucia Di Marcotullio,Azzura Greco,Sonia Coni,Laura Antonucci,Paola Infante,Laura Pietrosanti,Enrico De Smaele,Elisabetta Ferretti,Evelina Miele,Marianna Pelloni,Giuseppina De Simone,Emilia Pedone,Paola Gallinari,Alessandra Giorgi,Christian Steinkühler,Luigi Vitagliano,Carlo Pedone,M Eugenià Schinin,Isabella Screpanti,Alberto Gulino +20 more
TL;DR: It is shown that Gli1 and Gli2 are acetylated proteins and that their HDAC-mediated deacetylation promotes transcriptional activation and sustains a positive autoregulatory loop through Hedgehog-induced upregulation of HDAC1.