S
Stefanie Wanka
Researcher at Swiss Institute of Bioinformatics
Publications - 7
Citations - 1329
Stefanie Wanka is an academic researcher from Swiss Institute of Bioinformatics. The author has contributed to research in topics: Phosphorylation & Phosphoproteomics. The author has an hindex of 6, co-authored 7 publications receiving 1153 citations. Previous affiliations of Stefanie Wanka include University of Zurich.
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Journal ArticleDOI
Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling.
Frank Wippich,Bernd Bodenmiller,Maria Gustafsson Trajkovska,Stefanie Wanka,Ruedi Aebersold,Ruedi Aebersold,Lucas Pelkmans +6 more
TL;DR: During cellular stress, the dual specificity kinase DYRK3 regulates the stability of P-granule-like structures and mTORC1 signaling and links cytoplasmic compartmentalization via liquid phase transitions with cellular signaling.
Journal ArticleDOI
Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis
Alexandre Huber,Bernd Bodenmiller,Aino Uotila,Michael Stahl,Stefanie Wanka,Bertran Gerrits,Ruedi Aebersold,Ruedi Aebersold,Ruedi Aebersold,Robbie Loewith +9 more
TL;DR: Assessment of the rapamycin-sensitive phosphoproteomes in various genetic backgrounds revealed both documented and novel TORC1 effectors and allowed us to partition phosphorylation events between Tap42 and Sch9, demonstrating that Sch9 is a master regulator of protein synthesis.
Journal ArticleDOI
Phosphoproteomic Analysis Reveals Interconnected System-Wide Responses to Perturbations of Kinases and Phosphatases in Yeast
Bernd Bodenmiller,Stefanie Wanka,Claudine Kraft,Joerg Urban,David S. Campbell,Patrick G. A. Pedrioli,Bertran Gerrits,Paola Picotti,Henry H N Lam,Olga Vitek,Mi-Youn Brusniak,Bernd Roschitzki,Chao Zhang,Kevan M. Shokat,Ralph Schlapbach,Alejandro Colman-Lerner,Garry P. Nolan,Alexey I. Nesvizhskii,Matthias Peter,Robbie Loewith,Christian von Mering,Ruedi Aebersold,Ruedi Aebersold,Ruedi Aebersold +23 more
TL;DR: A system-wide analysis of protein phosphorylation in yeast reveals robustness in the network of kinases and phosphatases and reinforces the idea that simple linear representations of signaling pathways might be insufficient for drug development and for describing organismal homeostasis.
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The calcineurin signaling network evolves via conserved kinase-phosphatase modules that transcend substrate identity.
Aaron Goldman,Jagoree Roy,Bernd Bodenmiller,Stefanie Wanka,Christian R. Landry,Ruedi Aebersold,Ruedi Aebersold,Martha S. Cyert +7 more
TL;DR: In this paper, a functional network for calcineurin, the conserved Ca2+/calmodulin-regulated phosphatase, was defined by identifying its substrates in S. cerevisiae using phosphoproteomics and bioinformatics.
Journal ArticleDOI
A sentinel protein assay for simultaneously quantifying cellular processes
Martin Soste,Rita Hrabakova,Stefanie Wanka,Andre Melnik,Paul J. Boersema,Alessio Maiolica,Timon Wernas,Marco Tognetti,Christian von Mering,Paola Picotti +9 more
TL;DR: A proteomic screening approach based on the concept of sentinel proteins, biological markers whose change in abundance characterizes the activation state of a given cellular process, which can be applied to analyze responses to large sets of uncharacterized perturbations in high throughput.