Ralph Schlapbach

TL;DR: A culture-independent analysis of the microbiota associated with leaves of soybean, clover, and Arabidopsis thaliana plants using a metaproteogenomic approach is performed, finding a high consistency of the communities on the 3 different plant species, both with respect to the predominant community members (including the alphaproteobacterial genera Sphingomonas and Methylo bacterium) and withrespect to their proteomes.

TL;DR: It is concluded that ROS and NO are important physiological reactants in mitochondria and become toxic only when present in excessive amounts.

TL;DR: This study demonstrates that the acquisition of reproducible quantitative proteomics data by multiple labs is achievable, and broadly serves to increase confidence in SWATH-mass spectrometry data acquisition as a reproducible method for large-scale protein quantification.

TL;DR: A system-wide analysis of protein phosphorylation in yeast reveals robustness in the network of kinases and phosphatases and reinforces the idea that simple linear representations of signaling pathways might be insufficient for drug development and for describing organismal homeostasis.

TL;DR: It is shown that high-quality proteomics data provide crucial information to amend genome annotation and to confirm many predicted gene models, and this library of proteotypic peptides should enable fast, targeted and quantitative proteomic studies to elucidate the systems biology of this model organism.