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Stefano Ughetto
Researcher at Harvard University
Publications - 6
Citations - 847
Stefano Ughetto is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications receiving 274 citations. Previous affiliations of Stefano Ughetto include University of Turin.
Papers
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Journal ArticleDOI
RNA delivery by extracellular vesicles in mammalian cells and its applications.
Killian P. O’Brien,Koen Breyne,Stefano Ughetto,Stefano Ughetto,Louise C. Laurent,Xandra O. Breakefield +5 more
TL;DR: This Review focuses on the current state of knowledge pertaining to packaging, transport and function of RNAs in extracellular vesicles and outlines the progress made thus far towards their clinical applications.
Journal ArticleDOI
Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo
TL;DR: In this article , the authors demonstrate functional delivery of EV-encapsulated RNA and protein cargo through use of luminescence and fluorescence reporters by combining organelle-targeted nanoluciferase with fluorescent proteins.
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Using genetically modified extracellular vesicles as a non-invasive strategy to evaluate brain-specific cargo
David Rufino-Ramos,Sevda Lule,Shadi Mahjoum,Stefano Ughetto,D. Cristopher Bragg,Luís Pereira de Almeida,Xandra O. Breakefield,Koen Breyne +7 more
TL;DR: In this article , a transducible construct tagging tetraspanin (TSN) CD63, a membrane-spanning hallmark of EVs equipped with affinity, bioluminescent, and fluorescent tags to increase detection sensitivity and robustness in capture of EVs secreted from pre-labelled cells into biofluids.
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Exogenous loading of extracellular vesicles, virus-like particles, and lentiviral vectors with supercharged proteins
Koen Breyne,Stefano Ughetto,David Rufino-Ramos,Shadi Mahjoum,Emily A. Grandell,Luís Pereira de Almeida,Xandra O. Breakefield +6 more
TL;DR: In this paper , a nonenzymatic assembly of purified BVs, supercharged proteins, and plasmid DNA called pDNA-scBVs was introduced to mediate floxed reporter activation.
Journal ArticleDOI
Efficacy of CAR-T immunotherapy in MET overexpressing tumors not eligible for anti-MET targeted therapy
Cristina Chiriaco,Chiara Donini,Marco Cortese,Stefano Ughetto,Chiara Modica,Ilaria Martinelli,Alessia Proment,Letizia Vitali,Lara Fontani,Monica Casucci,Paolo M. Comoglio,Silvia Giordano,Dario Sangiolo,Valeria Leuci,Elisa Vigna +14 more
TL;DR: In this article , the authors proposed an immunotherapy strategy based on T lymphocytes expressing a Chimeric Antigen Receptor (CAR) targeting MET overexpressing tumors of different histotypes.