K
Koen Breyne
Researcher at Ghent University
Publications - 34
Citations - 1366
Koen Breyne is an academic researcher from Ghent University. The author has contributed to research in topics: Mastitis & Staphylococcus aureus. The author has an hindex of 12, co-authored 25 publications receiving 693 citations. Previous affiliations of Koen Breyne include University of Chicago & Harvard University.
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Journal ArticleDOI
RNA delivery by extracellular vesicles in mammalian cells and its applications.
Killian P. O’Brien,Koen Breyne,Stefano Ughetto,Stefano Ughetto,Louise C. Laurent,Xandra O. Breakefield +5 more
TL;DR: This Review focuses on the current state of knowledge pertaining to packaging, transport and function of RNAs in extracellular vesicles and outlines the progress made thus far towards their clinical applications.
Journal ArticleDOI
The Quorum Sensing Inhibitor Hamamelitannin Increases Antibiotic Susceptibility of Staphylococcus aureus Biofilms by Affecting Peptidoglycan Biosynthesis and eDNA Release
Gilles Brackman,Koen Breyne,Riet De Rycke,Arno Vermote,Filip Van Nieuwerburgh,Evelyne Meyer,Serge Van Calenbergh,Tom Coenye +7 more
TL;DR: Evidence is provided that Hamamelitannin (2′,5-di-O-galloyl-d-hamamelose; HAM) specifically affects S. aureus biofilm susceptibility through the TraP receptor by affecting cell wall synthesis and extracellular DNA release of S.Aureus.
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Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer
Jonas Steenbrugge,Koen Breyne,Koen Breyne,Kristel Demeyere,Olivier De Wever,Niek N. Sanders,Wim Van Den Broeck,Cecile Colpaert,Peter B. Vermeulen,Steven Van Laere,Evelyne Meyer +10 more
TL;DR: The current experimental study with an innovative immunocompetent intraductal model for TNBC pinpoints towards a metastasis-supporting M1 to M2 macrophage polarization in the mammary ducts mediated by 4T1-derived signaling as immunotherapeutic target.
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Hamamelitannin Analogues that Modulate Quorum Sensing as Potentiators of Antibiotics against Staphylococcus aureus.
Arno Vermote,Gilles Brackman,Martijn D. P. Risseeuw,Bieke Vanhoutte,Paul Cos,Kristof Van Hecke,Koen Breyne,Evelyne Meyer,Tom Coenye,Serge Van Calenbergh +9 more
TL;DR: The synthesis of 58 analogues of hamamelitannin (HAM), a quorum sensing inhibitor and antimicrobial potentiator, resulted in the identification of an analogue that increases the susceptibility of Staphylococcus aureus towards antibiotics in vitro, in Caenorhabditis elegans, and in a mouse mammary gland infection model, without showing cytotoxicity.
Journal ArticleDOI
Efficacy and Safety of a Bovine-Associated Staphylococcus aureus Phage Cocktail in a Murine Model of Mastitis
Koen Breyne,Ryan W. Honaker,Zachary Alan Hobbs,Manuela Richter,Maciej Żaczek,Taylor Spangler,Jonas Steenbrugge,Rebecca Lu,Anika Kinkhabwala,Bruno Marchon,Evelyne Meyer,Lucia Mokres +11 more
TL;DR: The in vivo results complement the in vitro data and support the concept of phage therapy as an innovative alternative or supplementation therapy to antibiotics for the treatment of bovine mastitis.