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Steffen Erkelenz
Researcher at University of Düsseldorf
Publications - 24
Citations - 626
Steffen Erkelenz is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: RNA splicing & Exonic splicing enhancer. The author has an hindex of 12, co-authored 24 publications receiving 520 citations. Previous affiliations of Steffen Erkelenz include University of Cologne.
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Journal ArticleDOI
Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms
Steffen Erkelenz,William F. Mueller,Melanie S. Evans,Anke Busch,Katrin Schöneweis,Klemens J. Hertel,Heiner Schaal +6 more
TL;DR: It is shown that SR and hnRNP splicing factors exploit similar mechanisms to positively or negatively influence splice site selection, based on their binding location relative to regulated 5' splice sites.
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Genomic HEXploring allows landscaping of novel potential splicing regulatory elements
TL;DR: The HEXplorer score allowed landscaping of splicing regulatory regions, provided a quantitative measure of mutation effects on splice enhancing and silencing properties and permitted calculation of the mutationally most effective nucleotide.
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Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold.
Kusum Kumari Singh,Steffen Erkelenz,Stephanie Rattay,Anna Katharina Dehof,Andreas Hildebrandt,Klaus Schulze-Osthoff,Heiner Schaal,Christian Schwerk +7 more
TL;DR: Coimmunoprecipitation and immunofluorescence experiments demonstrated that SAP18 assembles a nuclear speckle-localized splicing regulatory multiprotein complex including RNPS1 and Acinus via its ubiquitin-like fold, suggesting a novel function of SAP18 in splicing regulation.
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Behind the scenes of HIV-1 replication: Alternative splicing as the dependency factor on the quiet
TL;DR: The complex network of cis-acting splicing regulatory elements (SREs) are described, which are mainly localized in the neighbourhoods of all HIV-1 splice sites and warrant the proper ratio of individual transcript isoforms.
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Balanced splicing at the Tat-specific HIV-1 3′ss A3 is critical for HIV-1 replication
Steffen Erkelenz,Frank Hillebrand,Marek Widera,Stephan Theiss,Anaam Fayyaz,Daniel Degrandi,Klaus Pfeffer,Heiner Schaal +7 more
TL;DR: It is proposed that splicing at 3′ss A3 is dependent on binding of the enhancing SR proteins SRSF2 and S RSF6 to the ESEtat and ESE2 sequence, and that it is fundamental for regulated 3′SS A3 usage.