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William F. Mueller
Researcher at University of California, Irvine
Publications - 13
Citations - 481
William F. Mueller is an academic researcher from University of California, Irvine. The author has contributed to research in topics: RNA splicing & Alternative splicing. The author has an hindex of 7, co-authored 10 publications receiving 407 citations. Previous affiliations of William F. Mueller include University of California.
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Journal ArticleDOI
Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms
Steffen Erkelenz,William F. Mueller,Melanie S. Evans,Anke Busch,Katrin Schöneweis,Klemens J. Hertel,Heiner Schaal +6 more
TL;DR: It is shown that SR and hnRNP splicing factors exploit similar mechanisms to positively or negatively influence splice site selection, based on their binding location relative to regulated 5' splice sites.
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The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma
Guido von Figura,Akihisa Fukuda,Nilotpal Roy,Muluye E. Liku,John P. Morris,Grace E. Kim,Holger A. Russ,Matthew A. Firpo,Sean J. Mulvihill,David W. Dawson,Jorge Ferrer,William F. Mueller,Anke Busch,Klemens J. Hertel,Matthias Hebrok +14 more
TL;DR: This study implicates Brg1 as a determinant of context-dependent Kras-driven pancreatic tumorigenesis and suggests that chromatin remodelling may underlie the development of distinct PDA subsets.
Journal ArticleDOI
Competing upstream 5' splice sites enhance the rate of proximal splicing.
TL;DR: Results reveal the discovery of a new splicing regulatory element, an upstream 5′ splice site functioning as a splicing enhancer, and show that observed rates of splicing correlate well with their U1 snRNA base pairing potential.
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The Silent Sway of Splicing by Synonymous Substitutions.
TL;DR: It is demonstrated that coding and pre-mRNA splicing pressures co-evolve and that a modified phylogenetic comparison based on the exon/intron architecture is a useful tool in identifying splice altering SNPs.
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G Run-mediated Recognition of Proteolipid Protein and DM20 5′ Splice Sites by U1 Small Nuclear RNA Is Regulated by Context and Proximity to the Splice Site
TL;DR: In this article, the authors investigated the effect of splice site strength, distance, and context on G run function and found that G1M2 is necessary for initial recruitment of U1snRNP to the DM20 5′ splice sites.