Stela Gengrinovitch

TL;DR: Recent developments that have widened considerably the understanding of the mechanisms that control V EGF production and VEGF signal transduction are focused on and recent studies that have shed light on the mechanisms by which VEGf regulates angiogenesis are reviewed.

TL;DR: PF4 can bind to heparin binding proteins such as VEGF165 leading to an inhibition of their receptor binding ability, and it is observed that PF4 inhibits efficiently the V EGF165 induced proliferation of vascular endothelial cells.

TL;DR: It is suggested that glypican-1 may play an important role in the control of angiogenesis by regulating the activity of VEGF165, a regulation that may be critical under conditions such as wound repair, in which oxidizing agents that can impair theActivity of V EGF are produced, and in situations were the concentrations of active VEGf are limiting.

TL;DR: Experiments suggest that alternative splicing can generate a diversity in growth factor signaling by determining receptor recognition patterns and indicate that the heparin binding ability of VEGF may enable the restoration of damaged V EGF function in processes such as inflammation or wound healing.

TL;DR: The upregulation of Lox and Loxl2 in Wilson's disease could perhaps be utilized for diagnostic purposes since their expression is up-regulated in hepatocytes even before the onset of fibrosis.