Tzafra Cohen

TL;DR: Recent developments that have widened considerably the understanding of the mechanisms that control V EGF production and VEGF signal transduction are focused on and recent studies that have shed light on the mechanisms by which VEGf regulates angiogenesis are reviewed.

TL;DR: It is demonstrated using Northern analysis that treatment of various cell lines with IL-6 for 6-48 h results in a significant induction of VEGF mRNA, and it is shown that the 5′-UTR is important for the expression of V EGF.

TL;DR: Recombinant VEGF145 induced the proliferation of vascular endothelial cells and promoted angiogenesis in vivo and seems to possess a unique combination of biological properties distinct from those of previously characterized V EGF species.

TL;DR: It is reported that human umbilical vein-derived endothelial cells express the a17 and a22 splice forms of the np-2 receptor, and it is possible that VEGF-inducednp-2-mediated signaling will take place only in the presence of other V EGF receptors such as VEGFs receptor-1 or VEGf receptor-2.

TL;DR: Gene targeting experiments indicate that np1 does indeed function as an important modulator of VEGF function during vasculogenesis and angiogenesis, but the role of np2 in the cardiovascular system has not been studied in detail as yet.