Stephan J. Guyenet

TL;DR: Obesity is associated with neuronal injury in a brain area crucial for body weight control in both humans and rodent models, and evidence of increased gliosis in the mediobasal hypothalamus of obese humans is found.

TL;DR: The observational evidence does not support the hypothesis that dairy fat or high-fat dairy foods contribute to obesity or cardiometabolic risk, and suggests that high- fat dairy consumption within typical dietary patterns is inversely associated with obesity risk.

TL;DR: A protocol for the rapid and sensitive quantification of disease severity in mouse models of cerebella ataxia, derived from previously published phenotype assessments in several disease models, including spinocerebellar ataxias, Huntington s disease and spinobulbar muscular atrophy is described.

TL;DR: In this paper, the authors considered all relevant published research and cited references that represented the highest quality evidence available, where space permitted, primary references were cited, and concluded that the increase of energy intake that has fueled the U.S. obesity epidemic is linked to greater availability of highly rewarding/palatable and energy-dense food.

TL;DR: It is indicated that impairment of glutamate transport secondary to glial dysfunction contributes to SCA7 neurodegeneration, and a similar role for glia dysfunction in other polyglutamine diseases and SCAs is suggested.