S
Stephen A. Martin
Researcher at Applied Biosystems
Publications - 7
Citations - 4750
Stephen A. Martin is an academic researcher from Applied Biosystems. The author has contributed to research in topics: Matrix (chemical analysis) & Blood proteins. The author has an hindex of 6, co-authored 7 publications receiving 4560 citations.
Papers
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Journal ArticleDOI
Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-reactive Isobaric Tagging Reagents
Philip L. Ross,Yulin N. Huang,Jason Marchese,Brian L. Williamson,Kenneth C. Parker,Stephen J. Hattan,Nikita Khainovski,Sasi Pillai,Subhakar Dey,Scott Daniels,Subhasish Purkayastha,Peter Juhasz,Stephen A. Martin,Michael Bartlet-Jones,Feng He,Allan Jacobson,Darryl J. Pappin,Darryl J. Pappin +17 more
TL;DR: It is found that inactivation of Upf1p and Xrn1p causes common as well as unique effects on protein expression, and the use of 4-fold multiplexing to enable relative protein measurements simultaneously with determination of absolute levels of a target protein using synthetic isobaric peptide standards.
Journal ArticleDOI
Suppression of alpha-cyano-4-hydroxycinnamic acid matrix clusters and reduction of chemical noise in MALDI-TOF mass spectrometry
Igor P. Smirnov,X Zhu,T Taylor,Y Huang,Philip L. Ross,I A Papayanopoulos,Stephen A. Martin,Darryl J. Pappin +7 more
TL;DR: This sample preparation method resulted in improved spectral quality and was essential for successful database searching for subnanomolar concentrations of protein digests.
Patent
Method for characterizing biomolecules utilizing a result driven strategy
TL;DR: In this article, the authors provided a method for analyzing a sample using a result dependent acquisition strategy, in which the sample is first analyzed by MALDI and MS to produce a first result that is then used to determine a second analysis that is used to analyze the sample again by MS/MS or MSn.
Journal ArticleDOI
Identification of Amadori-Modified Plasma Proteins in Type 2 Diabetes and the Effect of Short-Term Intensive Insulin Treatment
Abdul Jaleel,Panagiotis Halvatsiotis,Brian L. Williamson,Peter Juhasz,Stephen A. Martin,K. Sreekumaran Nair +5 more
TL;DR: No significant differences in the glycation of proteins between the obese and lean groups were noted, but type 2 diabetic patients had several proteins with higher glycation than the control groups, and the potential for monitoring short-term glycemic control in diabetic patients is offered.
Journal ArticleDOI
Result‐driven strategies for protein identification and quantitation – a way to optimize experimental design and derive reliable results
Armin Graber,Peter Juhasz,Nikita Khainovski,Kenneth C. Parker,Dale H. Patterson,Stephen A. Martin +5 more
TL;DR: This work has shown that the off‐line coupling of μLC with MS quantitation and MS/MS identification methods makes new result‐dependent workflows possible and requires the development of innovative algorithms for these three result‐ dependent workflows that make MS andMS/MS analysis more efficient and also add confidence to experimental results.