S
Stephen Hibbs
Researcher at University of Maryland Biotechnology Institute
Publications - 7
Citations - 350
Stephen Hibbs is an academic researcher from University of Maryland Biotechnology Institute. The author has contributed to research in topics: Bacillus anthracis & Exosporium. The author has an hindex of 6, co-authored 7 publications receiving 341 citations. Previous affiliations of Stephen Hibbs include University of Maryland, College Park.
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Journal ArticleDOI
Murine Macrophages Kill the Vegetative Form of Bacillus anthracis
Tae Jin Kang,Matthew J. Fenton,Matthew A. Weiner,Stephen Hibbs,Subhendu Basu,Les Baillie,Les Baillie,Alan S. Cross +7 more
TL;DR: It is concluded that macrophages appear unable to kill the spore form of B. anthracis and that the exosporium may play a role in the protection of spores from macrophage.
Journal ArticleDOI
Importance of Nitric Oxide Synthase in the Control of Infection by Bacillus anthracis
Kimberly W. Raines,Tae Jin Kang,Stephen Hibbs,Guan-Liang Cao,Guan-Liang Cao,John Weaver,John Weaver,Pei Tsai,Pei Tsai,Les Baillie,Les Baillie,Alan S. Cross,Gerald M. Rosen,Gerald M. Rosen +13 more
TL;DR: As macrophage-generated NO· is an important pathway in microbial killing, the ability of endospores of B. anthracis to regulate production of this free radical has important implications in the control of bacilli and endospore-mediated infection.
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Protective Role of Bacillus anthracis Exosporium in Macrophage-Mediated Killing by Nitric Oxide
John Weaver,Tae Jin Kang,Kimberly W. Raines,Guan-Liang Cao,Guan-Liang Cao,Stephen Hibbs,Pei Tsai,Pei Tsai,Les Baillie,Les Baillie,Gerald M. Rosen,Gerald M. Rosen,Alan S. Cross +12 more
TL;DR: The findings suggest that ONOO− was formed upon macrophage infection by B. anthracis endospores, but does not appear to exhibit microbicidal activity toward this bacterium, which has important implications in the control of B. Anthracis-induced infection.
Journal ArticleDOI
Role of superoxide in the germination of Bacillus anthracis endospores.
Les Baillie,Les Baillie,Stephen Hibbs,Pei Tsai,Pei Tsai,Guan-Liang Cao,Guan-Liang Cao,Gerald M. Rosen,Gerald M. Rosen +8 more
TL;DR: Data presented herein suggest that B. anthracis may co-opt O(2)*- which is produced by stimulated myeloid phagocytes and is an essential element of host immunity, as a necessary step in productive infection of the host.
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Microwave-accelerated metal-enhanced fluorescence: application to detection of genomic and exosporium anthrax DNA in <30 seconds
TL;DR: This study has set the stage and indeed provides an opportunity for the ultra-fast and specific detection of B. anthracis spores with minimal pre-processing steps using a relatively simple but cost-effective technology that could minimize casualties in the event of another anthrax attack.