S
Stephen J. Tucker
Researcher at University of Oxford
Publications - 158
Citations - 9006
Stephen J. Tucker is an academic researcher from University of Oxford. The author has contributed to research in topics: Gating & Potassium channel. The author has an hindex of 47, co-authored 143 publications receiving 8165 citations. Previous affiliations of Stephen J. Tucker include Kyoto University & Pontifical Catholic University of Chile.
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Journal ArticleDOI
Truncation of Kir6.2 produces ATP-sensitive K + channels in the absence of the sulphonylurea receptor
TL;DR: It is shown that the primary site at which ATP acts to mediate K-ATP channel inhibition is located on Kir6.2, and that SUR1 is required for sensitivity to sulphonylureas and diazoxide and for activation by Mg-ADP.
Journal ArticleDOI
PIP2 and PIP as Determinants for ATP Inhibition of KATP Channels
Thomas Baukrowitz,Uwe Schulte,Dominik Oliver,Stefan Herlitze,Tobias Krauter,Stephen J. Tucker,J. Peter Ruppersberg,Bernd Fakler +7 more
TL;DR: It is reported here that phosphatidylinositol-4, 5-bisphosphate (PIP2) and phosphorus-4-phosphates(PIP) controlled ATP inhibition of cloned KATP channels (Kir6.2 and SUR1) and represents a mechanism for control of excitability through phospholipids.
Journal ArticleDOI
The essential role of the Walker A motifs of SUR1 in K‐ATP channel activation by Mg‐ADP and diazoxide
TL;DR: The results indicate that the WA lysine of NBD1 (but not NBD2) is essential for activation of K‐ATP currents by diazoxide, and Mutant currents were slightly more sensitive to ATP than wild‐type currents.
Journal ArticleDOI
A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura.
Ronald G. Lafrenière,M. Zameel Cader,M. Zameel Cader,Jean-François Poulin,Isabelle Andres-Enguix,Maryse Simoneau,Namrata Gupta,Karine Boisvert,François Lafrenière,Shannon McLaughlan,Marie-Pierre Dubé,Martin M Marcinkiewicz,Sreeram V. Ramagopalan,Olaf Ansorge,Bernard Brais,Jorge Sequeiros,José Pereira-Monteiro,Lyn R. Griffiths,Stephen J. Tucker,George C. Ebers,Guy A. Rouleau +20 more
TL;DR: A frameshift mutation, F139WfsX24, is reported, which segregates perfectly with typical migraine with aura in a large pedigree and demonstrates that it causes a complete loss of TRESK function and that the mutant subunit suppresses wild-type channel function through a dominant-negative effect, thus explaining the dominant penetrance of this allele.
A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura
Ronald G. Lafrenière,M. Zameel Cader,M. Zameel Cader,Jean-François Poulin,Isabelle Andres-Enguix,Maryse Simoneau,Namrata Gupta,Karine Boisvert,François Lafrenière,Shannon McLaughlan,Marie-Pierre Dubé,Martin M Marcinkiewicz,Sreeram V. Ramagopalan,Olaf Ansorge,Bernard Brais,Jorge Sequeiros,José Pereira-Monteiro,Lyn R. Griffiths,Stephen J. Tucker,George C. Ebers,Guy A. Rouleau +20 more
TL;DR: In this article, a frameshift mutation, F139WfsX24, was found to cause complete loss of TRESK function and that the mutant subunit suppresses wild-type channel function through a dominant negative effect, thus explaining the dominant penetrance of this allele.