H
Harvey O. Coxson
Researcher at University of British Columbia
Publications - 269
Citations - 25197
Harvey O. Coxson is an academic researcher from University of British Columbia. The author has contributed to research in topics: COPD & Spirometry. The author has an hindex of 80, co-authored 263 publications receiving 22363 citations. Previous affiliations of Harvey O. Coxson include Vancouver General Hospital & Boston University.
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Journal ArticleDOI
The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
James C. Hogg,Fanny Chu,Soraya Utokaparch,Ryan Woods,W. Mark Elliott,Liliana Buzatu,Ruben M. Cherniack,Robert M. Rogers,Frank C. Sciurba,Harvey O. Coxson,Peter D. Paré +10 more
TL;DR: Progression of COPD is associated with the accumulation of inflammatory mucous exudates in the lumen and infiltration of the wall by innate and adaptive inflammatory immune cells that form lymphoid follicles, coupled to a repair or remodeling process that thickens the walls of these airways.
Journal ArticleDOI
Characterisation of COPD heterogeneity in the ECLIPSE cohort
Alvar Agusti,Peter M.A. Calverley,Bartolome R. Celli,Harvey O. Coxson,Lisa D. Edwards,David A. Lomas,William MacNee,Bruce E. Miller,S.I. Rennard,Edwin K. Silverman,Ruth Tal-Singer,Emiel F.M. Wouters,Julie C. Yates,Jørgen Vestbo +13 more
TL;DR: The clinical manifestations of COPD are highly variable and the degree of airflow limitation does not capture the heterogeneity of the disease.
Journal ArticleDOI
Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease
John E. McDonough,Ren Yuan,Masaru Suzuki,Nazgol Seyednejad,W. Mark Elliott,Pablo G. Sanchez,Alexander C. Wright,Warren B. Gefter,Leslie A. Litzky,Harvey O. Coxson,Peter D. Paré,Don D. Sin,Richard A. Pierce,Jason C. Woods,Annette McWilliams,John R. Mayo,Stephen Lam,Joel D. Cooper,James C. Hogg +18 more
TL;DR: Results show that narrowing and disappearance of small conducting airways before the onset of emphysematous destruction can explain the increased peripheral airway resistance reported in COPD.
Journal ArticleDOI
Changes in forced expiratory volume in 1 second over time in copd
Jørgen Vestbo,Jørgen Vestbo,Lisa D. Edwards,Paul D. Scanlon,Julie C. Yates,Alvar Agusti,Per Bakke,Peter M.A. Calverley,Bartolome R. Celli,Harvey O. Coxson,Courtney Crim,David A. Lomas,William MacNee,Bruce E. Miller,Edwin K. Silverman,Ruth Tal-Singer,Emiel F.M. Wouters,Stephen I. Rennard +17 more
TL;DR: The rate of change in FEV(1) among patients with COPD is highly variable, with increased rates of decline among current smokers, patients with bronchodilator reversibility, and patients with emphysema.
Journal ArticleDOI
Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype.
Alvar Agusti,Lisa D. Edwards,Stephen I. Rennard,William MacNee,Ruth Tal-Singer,Bruce E. Miller,Jørgen Vestbo,Jørgen Vestbo,David A. Lomas,Peter M.A. Calverley,Emiel F.M. Wouters,Courtney Crim,Julie C. Yates,Edwin K. Silverman,Harvey O. Coxson,Per Bakke,Ruth J. Mayer,Bartolome R. Celli +17 more
TL;DR: Overall, the results identify a novel systemic inflammatory COPD phenotype that may be the target of specific research and treatment and show associations but do not prove causality.