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Ignacio I. Wistuba
Researcher at University of Texas Health Science Center at Houston
Publications - 98
Citations - 6329
Ignacio I. Wistuba is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Loss of heterozygosity & Cancer. The author has an hindex of 38, co-authored 98 publications receiving 6016 citations. Previous affiliations of Ignacio I. Wistuba include University of Texas MD Anderson Cancer Center & University of La Frontera.
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Journal ArticleDOI
Molecular Damage in the Bronchial Epithelium of Current and Former Smokers
Ignacio I. Wistuba,Stephen Lam,Carmen Behrens,Arvind K. Virmani,Kwun M. Fong,Jean C. LeRiche,Jonathan M. Samet,Sudhir Srivastava,John D. Minna,Adi F. Gazdar +9 more
TL;DR: Genetic changes similar to those found in lung cancers can be detected in the nonmalignant bronchial epithelium of current and former smokers and may persist for many years after smoking cessation.
Journal Article
High Resolution Chromosome 3p Allelotyping of Human Lung Cancer and Preneoplastic/Preinvasive Bronchial Epithelium Reveals Multiple, Discontinuous Sites of 3p Allele Loss and Three Regions of Frequent Breakpoints
Ignacio I. Wistuba,Carmen Behrens,Arvind K. Virmani,Gina M. Mele,Sara Milchgrub,Luc Girard,John W. Fondon,Harold R. Garner,Bruce McKay,Farida Latif,Michael I. Lerman,Stephen Lam,Adi F. Gazdar,John D. Minna +13 more
TL;DR: It is concluded that 3p allele loss is nearly universal in lung cancer pathogenesis; involves multiple, discrete, 3p LOH sites that often show a "discontinuous LOH" pattern in individual tumors; occurs in preneoplastic/preinvasive lesions in smokers with and without lung cancer (multiple lesions often lose the same parental allele).
Journal ArticleDOI
Molecular genetics of small cell lung carcinoma.
Ignacio I. Wistuba,Ignacio I. Wistuba,Adi F. Gazdar,Adi F. Gazdar,John D. Minna,John D. Minna +5 more
TL;DR: The smoking-damaged bronchial epithelium accompanying SCLC and NSCLC appears to have undergone significantly more acquired genetic damage than that accompanying NSCLCs, and there is clear evidence on a genome-wide scale that SCLCs do differ significantly in the TSGs that are inactivated during their pathogenesis.
Journal ArticleDOI
Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma
Ignacio I. Wistuba,Carmen Behrens,Sara Milchgrub,David Bryant,Jaclyn Y. Hung,Jaclyn Y. Hung,John D. Minna,Adi F. Gazdar +7 more
TL;DR: It is indicated that multiple, sequentially occurring allele specific molecular changes commence in widely dispersed, apparently clonally independent foci, early in the multistage pathogenesis of squamous cell carcinomas of the lung.
Journal Article
Characterization of a Breast Cancer Cell Line Derived from a Germ-Line BRCA1 Mutation Carrier
Gail E. Tomlinson,Tina T-L. Chen,Victor Stastny,Arvind K. Virmani,Monique A. Spillman,Vijay S. Tonk,Joanne L. Blum,Nancy R. Schneider,Ignacio I. Wistuba,Jerry W. Shay,John D. Minna,Adi F. Gazdar +11 more
TL;DR: This breast tumor-derived cell line may provide a useful model system for the study of familial breast cancer pathogenesis and for elucidating BRCA1 function and localization.