Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268

http://midag.cs.unc.edu/pubs/papers/Neuroimage06_Yushkevich.pdf

User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability

The analysis of medical images has been woven into the fabric of the pattern analysis and machine intelligence (PAMI) community since the earliest days of these Transactions. Initially, the efforts in this area were seen as applying pattern analysis and computer vision techniques to another interesting dataset. However, over the last two to three decades, the unique nature of the problems presented within this area of study have led to the development of a new discipline in its own right. Examples of these include: the types of image information that are acquired, the fully three-dimensional image data, the nonrigid nature of object motion and deformation, and the statistical variation of both the underlying normal and abnormal ground truth. In this paper, we look at progress in the field over the last 20 years and suggest some of the challenges that remain for the years to come.

https://hal.inria.fr/inria-00615100/document

Medical image analysis: progress over two decades and the challenges ahead

Humans perceive the three-dimensional structure of the world with apparent ease. However, despite all of the recent advances in computer vision research, the dream of having a computer interpret an image at the same level as a two-year old remains elusive. Why is computer vision such a challenging problem and what is the current state of the art? Computer Vision: Algorithms and Applications explores the variety of techniques commonly used to analyze and interpret images. It also describes challenging real-world applications where vision is being successfully used, both for specialized applications such as medical imaging, and for fun, consumer-level tasks such as image editing and stitching, which students can apply to their own personal photos and videos. More than just a source of recipes, this exceptionally authoritative and comprehensive textbook/reference also takes a scientific approach to basic vision problems, formulating physical models of the imaging process before inverting them to produce descriptions of a scene. These problems are also analyzed using statistical models and solved using rigorous engineering techniques Topics and features: structured to support active curricula and project-oriented courses, with tips in the Introduction for using the book in a variety of customized courses; presents exercises at the end of each chapter with a heavy emphasis on testing algorithms and containing numerous suggestions for small mid-term projects; provides additional material and more detailed mathematical topics in the Appendices, which cover linear algebra, numerical techniques, and Bayesian estimation theory; suggests additional reading at the end of each chapter, including the latest research in each sub-field, in addition to a full Bibliography at the end of the book; supplies supplementary course material for students at the associated website, http://szeliski.org/Book/. Suitable for an upper-level undergraduate or graduate-level course in computer science or engineering, this textbook focuses on basic techniques that work under real-world conditions and encourages students to push their creative boundaries. Its design and exposition also make it eminently suitable as a unique reference to the fundamental techniques and current research literature in computer vision.

/pdf/computer-vision-algorithms-and-applications-25dn6wu83j.pdf

Computer Vision: Algorithms and Applications

The multiscale second order local structure of an image (Hessian) is examined with the purpose of developing a vessel enhancement filter. A vesselness measure is obtained on the basis of all eigenvalues of the Hessian. This measure is tested on two dimensional DSA and three dimensional aortoiliac and cerebral MRA data. Its clinical utility is shown by the simultaneous noise and background suppression and vessel enhancement in maximum intensity projections and volumetric displays.

/pdf/muliscale-vessel-enhancement-filtering-3g7prwx990.pdf

Muliscale Vessel Enhancement Filtering

Adaptive histogram equalization (ahe) is a contrast enhancement method designed to be broadly applicable and having demonstrated effectiveness. However, slow speed and the overenhancement of noise it produces in relatively homogeneous regions are two problems. We report algorithms designed to overcome these and other concerns. These algorithms include interpolated ahe, to speed up the method on general purpose computers; a version of interpolated ahe designed to run in a few seconds on feedback processors; a version of full ahe designed to run in under one second on custom VLSI hardware; weighted ahe, designed to improve the quality of the result by emphasizing pixels' contribution to the histogram in relation to their nearness to the result pixel; and clipped ahe, designed to overcome the problem of overenhancement of noise contrast. We conclude that clipped ahe should become a method of choice in medical imaging and probably also in other areas of digital imaging, and that clipped ahe can be made adequately fast to be routinely applied in the normal display sequence.

Adaptive histogram equalization and its variations

The Image Processing Handbook

A primary goal of statistical shape analysis is to describe the variability of a population of geometric objects. A standard technique for computing such descriptions is principal component analysis. However, principal component analysis is limited in that it only works for data lying in a Euclidean vector space. While this is certainly sufficient for geometric models that are parameterized by a set of landmarks or a dense collection of boundary points, it does not handle more complex representations of shape. We have been developing representations of geometry based on the medial axis description or m-rep. While the medial representation provides a rich language for variability in terms of bending, twisting, and widening, the medial parameters are not elements of a Euclidean vector space. They are in fact elements of a nonlinear Riemannian symmetric space. In this paper, we develop the method of principal geodesic analysis, a generalization of principal component analysis to the manifold setting. We demonstrate its use in describing the variability of medially-defined anatomical objects. Results of applying this framework on a population of hippocampi in a schizophrenia study are presented.

/pdf/principal-geodesic-analysis-for-the-study-of-nonlinear-2pfw4drd5s.pdf

Principal geodesic analysis for the study of nonlinear statistics of shape

The purpose of this project was to determine whether Contrast Limited Adaptive Histogram Equalization (CLAHE) improves detection of simulated spiculations in dense mammograms Lines simulating the appearance of spiculations, a common marker of malignancy when visualized with masses, were embedded in dense mammograms digitized at 50 micron pixels, 12 bits deep Film images with no CLAHE applied were compared to film images with nine different combinations of clip levels and region sizes applied A simulated spiculation was embedded in a background of dense breast tissue, with the orientation of the spiculation varied The key variables involved in each trial included the orientation of the spiculation, contrast level of the spiculation and the CLAHE settings applied to the image Combining the 10 CLAHE conditions, 4 contrast levels and 4 orientations gave 160 combinations The trials were constructed by pairing 160 combinations of key variables with 40 backgrounds Twenty student observers were asked to detect the orientation of the spiculation in the image There was a statistically significant improvement in detection performance for spiculations with CLAHE over unenhanced images when the region size was set at 32 with a clip level of 2, and when the region size was set at 32 with a clip level of 4 The selected CLAHE settings should be tested in the clinic with digital mammograms to determine whether detection of spiculations associated with masses detected at mammography can be improved

Contrast limited adaptive histogram equalization image processing to improve the detection of simulated spiculations in dense mammograms.

An experiment intended to evaluate the clinical application of contrast-limited adaptive histogram equalization (CLAHE) to chest computer tomography (CT) images is reported. A machine especially designed to compute CLAHE in a few seconds is discussed. It is shown that CLAHE can be computed in 4 s after 5-s loading time using the specially designed parallel engine made from a few thousand dollars worth of off-the-shelf components. The processing appears to be useful for a wide range of medical images, but the limitations of observer calibration make it impossible to demonstrate such usefulness by agreement experiments. >

/pdf/contrast-limited-adaptive-histogram-equalization-speed-and-2310q59joe.pdf

Stephen M. Pizer

Papers

Adaptive histogram equalization and its variations

The Image Processing Handbook

Principal geodesic analysis for the study of nonlinear statistics of shape

Contrast limited adaptive histogram equalization image processing to improve the detection of simulated spiculations in dense mammograms.

Contrast-limited adaptive histogram equalization: speed and effectiveness