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Stephen McLaughlin
Researcher at Heriot-Watt University
Publications - 469
Citations - 12016
Stephen McLaughlin is an academic researcher from Heriot-Watt University. The author has contributed to research in topics: Turbo code & Lidar. The author has an hindex of 51, co-authored 449 publications receiving 10648 citations. Previous affiliations of Stephen McLaughlin include University of Edinburgh & University of Toulouse.
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Complex-valued radial basis function network, Part I: network architecture and learning algorithms
TL;DR: A complex radial basis function network has complex centres and connection weights, but the nonlinearity of its hidden nodes remains a real-valued function, and it provides a powerful tool for nonlinear signal processing involving complex signals.
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Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis.
MacDonald J. Christie,Robert N. Jorissen,Dmitri Mouradov,Anuratha Sakthianandeswaren,Shan Li,Felix R. Day,Felix R. Day,Cary Tsui,Lara Lipton,Lara Lipton,Jayesh Desai,Jayesh Desai,Ian T. Jones,Stephen McLaughlin,Robyn L. Ward,Nicholas J. Hawkins,Andrew Ruszkiewicz,James Moore,Antony W. Burgess,Dana A. Busam,Qi Zhao,Robert L. Strausberg,Robert L. Strausberg,A J Simpson,A J Simpson,Ian Tomlinson,Peter Gibbs,Peter Gibbs,Oliver M. Sieber,Oliver M. Sieber +29 more
TL;DR: APC genotypes in sporadic CRCs demonstrate ‘fine-tuned’ interdependence of hits by type and location, consistent with selection for particular residual levels of WNT/β-catenin signalling, with different ‘optimal’ thresholds for proximal and distal cancers.
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On Demodulation, Ridge Detection, and Synchrosqueezing for Multicomponent Signals
TL;DR: Numerical results show the benefits of the proposed approach for mode reconstruction in comparison to similar techniques that do not make use of demodulation, and numerical investigations show that the proposed Approach sharpens the TF representation on which it is built.
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PIK3CA and PTEN Gene and Exon Mutation-Specific Clinicopathologic and Molecular Associations in Colorectal Cancer
Fiona Day,Robert N. Jorissen,Lara Lipton,Dmitri Mouradov,Anuratha Sakthianandeswaren,Michael Christie,Shan Li,Cary Tsui,Jeanne Tie,Jayesh Desai,Zheng-Zhou Xu,Peter L. Molloy,Vicki L. J. Whitehall,Barbara A. Leggett,Ian T. Jones,Stephen McLaughlin,Robyn L. Ward,Nicholas J. Hawkins,Andrew Ruszkiewicz,James Moore,Dana A. Busam,Qi Zhao,Robert L. Strausberg,Peter Gibbs,Oliver M. Sieber +24 more
TL;DR: The data highlight the PI3K pathway as a therapeutic target in distinct colorectal cancer subtypes, with PIK3CA exon 20 and PTEN mutations associated with features of the sessile-serrated pathway (MSI-H/CIMP-L/KRASmut) of tumorigenesis.
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Investigation and Performance Enhancement of the Empirical Mode Decomposition Method Based on a Heuristic Search Optimization Approach
TL;DR: The optimization of both the interpolation points and the piecewise interpolating polynomials for the formation of the upper and lower envelopes of the signal reveal important characteristics of the method which where previously hidden, leading to significant performance improvements.