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Stephen O'Leary

Researcher at University of Melbourne

Publications -  252
Citations -  8139

Stephen O'Leary is an academic researcher from University of Melbourne. The author has contributed to research in topics: Cochlear implant & Hearing loss. The author has an hindex of 45, co-authored 238 publications receiving 6841 citations. Previous affiliations of Stephen O'Leary include Cochlear Limited & University of Sydney.

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Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons

TL;DR: Guinea pigs implanted with electrically stimulated Ppy/pTS/NT3-coated electrodes had lower electrically-evoked auditory brainstem response thresholds and greater SGN densities in implanted cochleae compared to non-implanted cochlearae and compared to animals implanted with Ppy-pTS-coating electrodes (p<0.05).
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The effect of polypyrrole with incorporated neurotrophin-3 on the promotion of neurite outgrowth from auditory neurons.

TL;DR: If applied to the cochlear implant, Ppy/pTS/NT3 will provide a biocompatible, low-impedance substrate for storage and release of NT3 to help protect auditory neurons from degradation after sensorineural hearing loss and encourage neurite outgrowth towards the electrodes.
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Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3.

TL;DR: Examination of the morphological effects on auditory neurons following deafening and the administration of brain‐derived neurotrophic factor and neurotrophin‐3 showed that neurotrophins were effective in preventing death of auditory neurons if administered 5 days after deafening or in preventing the continued loss of neurons if the administration was delayed by 33 days.